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Gender effects of nanoplastics and emerging contaminants mixtures in Mytilus galloprovincialis

2025-02Journal article Restricted access
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dc.contributor.authorRibeiro Gonçalves, Joanna Melissa
dc.contributor.authorBenedetti, M.
dc.contributor.authord'Errico, G.
dc.contributor.authorRegoli, F.
dc.contributor.authorBebianno, Maria
dc.date.accessioned2025-02-06T14:20:11Z
dc.date.available2025-02-06T14:20:11Z
dc.date.issued2025-02
dc.description.abstractThe reproduction of mussels occurs within the water column, and if gametogenesis is successful, gametes are exposed to the surrounding contaminants. Nanoplastics and other emerging contaminants have been gaining vast attention; however, their effects on the reproductive tissues of mussels with sex differentiation are scarce. Here, the effects of polystyrene nanoparticles (50 nm; 10 mu g/L), the cytotoxic drug 5-fluorouracil (10 ng/L), and a mixture of the two were evaluated in the gonads of Mytilus galloprovincialis after a 21-day exposure for a multibiomarker assessment, and after 28 days for the accumulation of nanoplastics. The effects on the activity of superoxide dismutase, catalase, glutathione-S-transferase, and lipid peroxidation were evaluated. Moreover, synergistic and antagonistic interactions in the mixture were calculated. A weight of evidence model was also used to elaborate on the hazardous level of biomarker results relative to polystyrene nanoparticles alone and in the mixture. The accumulation of nanoplastics appeared gender and time-specific, with females mostly compromised. According to the data set, a synergistic interaction between the cytotoxic drug and the nano- plastics makes the combination far more dangerous than individual stressors. The Weight Of Evidence model also confirms that females are more compromised at chronic exposure times than males. This study shows that the uptake, fate, and impact of emerging contaminants of concern can be significantly influenced by sex.eng
dc.description.sponsorshipJPIOCEANS/0005/2020; ALG-01–0145-FEDER-030922; UID/00350/2020
dc.identifier.doi10.1016/j.aquatox.2024.107219
dc.identifier.issn0166-445X
dc.identifier.urihttp://hdl.handle.net/10400.1/26751
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationEmerging: Environmental Mixtures of Emerging contaminants Repercussions on Gonads and Impact on Next Generations
dc.relationAquatic Research Infrastructure Network
dc.relation.ispartofAquatic Toxicology
dc.rights.uriN/A
dc.subjectMale
dc.subjectFemale
dc.subjectMussels
dc.subjectPolystyrene nanoplastics
dc.subject5-Fluorouracil
dc.subjectGonads
dc.titleGender effects of nanoplastics and emerging contaminants mixtures in Mytilus galloprovincialiseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEmerging: Environmental Mixtures of Emerging contaminants Repercussions on Gonads and Impact on Next Generations
oaire.awardTitleAquatic Research Infrastructure Network
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F150758%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0069%2F2020/PT
oaire.citation.titleAquatic Toxicology
oaire.citation.volume279
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRibeiro Gonçalves
person.familyNameBebianno
person.givenNameJoanna Melissa
person.givenNameMaria
person.identifier.ciencia-id2D1D-F33A-FB48
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0002-3242-1032
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationb34966cb-6747-46eb-b8a3-db09589d39af
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscoveryb34966cb-6747-46eb-b8a3-db09589d39af
relation.isProjectOfPublication658c0301-4227-4b0d-8061-2732d5648e71
relation.isProjectOfPublication5af011f9-3888-449a-a18c-d08b59e87091
relation.isProjectOfPublication.latestForDiscovery658c0301-4227-4b0d-8061-2732d5648e71

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