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Fish lysozyme gene family evolution and divergent function in early development

2021-01Journal article Restricted access
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dc.contributor.authorLi, Lisen
dc.contributor.authorCardoso, João C. R.
dc.contributor.authorFélix, Rute
dc.contributor.authorMateus, Ana Patricia
dc.contributor.authorCanario, Adelino
dc.contributor.authorPower, Deborah M.
dc.date.accessioned2021-09-08T10:58:16Z
dc.date.available2021-09-08T10:58:16Z
dc.date.issued2021-01
dc.description.abstractLysozymes are an ancient group of antimicrobial enzymes of the innate immune system. Here we provide a comparative analysis of the evolution and function of lysozymes during early development in fish, the most speciose vertebrate group. In fishes, lineage and species-specific evolution of both C-type (chicken or conventional) and G-type (goose type) genes occurred. Phylogenetic analysis revealed that the teleost lysozyme G-type members group with the tetrapod homologues but the teleost C-type form three different clusters with the tetrapods. Most of the teleost C-type cluster with tetrapod Lyz but there are some that group with the mammalian Lyzl1/2 and LALBA. This suggests that early in gnathostome evolution these genes already existed and that lyzl1/2 and lalba genes are present in fish and tetrapods. Gene synteny analysis to confirm sequence orthologies failed to identify conserved genome regions between teleosts and other vertebrates lysozyme gene regions suggesting that in the ancestral bony fish genome lyz, lyzl1/2, lalba and lyg precursor genes were transposed to different chromosome regions. The homologue of the mammalian lactalbumin (LALBA) gene was identified for the first time in teleosts and was expressed in skin and during egg and larval development. Lysozyme activity was detected in teleost eggs and varied between species and in the gilthead sea bream lyg and lalba transcript abundance differed in eggs and larvae from different brood stock suggesting differences exist in maternal innate immune protection.
dc.description.sponsorshipFCT Foundation for Science and TechnologyPortuguese Foundation for Science and Technology [727610]; FCTPortuguese Foundation for Science and TechnologyEuropean Commission [UIDB/04326/2020]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.dci.2020.103772
dc.identifier.issn0145-305X
dc.identifier.urihttp://hdl.handle.net/10400.1/17075
dc.language.isoeng
dc.peerreviewedyes
dc.publisherELSEVIER SCI LTD
dc.relationConsumer driven Production: Integrating Innovative Approaches for Competitive and Sustainable Performance across the Mediterranean Aquaculture Value Chain
dc.relationAlgarve Centre for Marine Sciences
dc.subjectLysozymes
dc.subjectEvolution
dc.subjectFish
dc.subjectInnate immunity
dc.subjectOntogeny
dc.subject.otherFisheries; Immunology; Veterinary Sciences; Zoology
dc.titleFish lysozyme gene family evolution and divergent function in early development
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleConsumer driven Production: Integrating Innovative Approaches for Competitive and Sustainable Performance across the Mediterranean Aquaculture Value Chain
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/727610/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.citation.startPage103772
oaire.citation.titleDevelopmental and Comparative Immunology
oaire.citation.volume114
oaire.fundingStreamH2020
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCardoso
person.familyNameFélix
person.familyNameMateus
person.familyNameCanario
person.familyNamePower
person.givenNameJoão
person.givenNameRute
person.givenNameAna Patrícia
person.givenNameAdelino
person.givenNameDeborah Mary
person.identifier14332
person.identifier143624
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-idFB1A-1325-8E25
person.identifier.ciencia-id2816-E389-626E
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0002-4144-3452
person.identifier.orcid0000-0003-2045-1047
person.identifier.orcid0000-0002-6244-6468
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.ridM-6164-2013
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id56006773000
person.identifier.scopus-author-id56568523700
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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