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Chitosan-dextran sulfate hydrogels as a potential carrier for probiotics

2017-09Journal article Open access
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dc.contributor.authorFalco, Cigdem Yucel
dc.contributor.authorFalkman, Peter
dc.contributor.authorRisbo, Jens
dc.contributor.authorCardenas, Marite
dc.contributor.authorMedronho, Bruno
dc.date.accessioned2019-11-20T15:07:21Z
dc.date.available2019-11-20T15:07:21Z
dc.date.issued2017-09
dc.description.abstractPhysical and chemical (crosslinked with genipin) hydrogels based on chitosan and dextran sulfate were developed and characterized as novel bio-materials suitable for probiotic encapsulation. The swelling of the hydrogels was dependent on the composition and weakly influenced by the pH of the media. The morphology analysis supports the swelling data showing distinct changes in microstructure depending on the composition. The viability and culturability tests showed approx. 3.6 log CFLI/mL decrease of cells (L acidophilus as model) incorporated into chemical hydrogels when compared to the number of viable native cells. However, the live/dead viability assay evidenced that a considerable amount of viable cells were still entrapped in the hydrogel network and therefore the viability is most likely underestimated. Overall, the developed systems are robust and their structure, rheology and swelling properties can be tuned by changing the blend ratio, thus constituting appealing bio-matrices for cell encapsulation. (C) 2017 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipPeople Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7/under REA grant [606713]
dc.description.sponsorshipPortuguese Foundation for Science and Technology (FCT) [PTDC/AGR-TEC/4814/2014, IF/01005/2014]
dc.description.sponsorshipSwedish Research Council
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.carbpol.2017.04.047
dc.identifier.issn0144-8617
dc.identifier.issn1879-1344
dc.identifier.urihttp://hdl.handle.net/10400.1/12996
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDrug-delivery
dc.subjectGenipin
dc.subjectBehavior
dc.titleChitosan-dextran sulfate hydrogels as a potential carrier for probiotics
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage183
oaire.citation.startPage175
oaire.citation.titleCarbohydrate Polymers
oaire.citation.volume172
person.familyNameMedronho
person.givenNameBruno
person.identifier.ciencia-id6918-9AB3-8D22
person.identifier.orcid0000-0003-0972-1739
person.identifier.ridP-5927-2014
person.identifier.scopus-author-id9940656700
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication4c03571a-93da-4504-8acf-c74326449852
relation.isAuthorOfPublication.latestForDiscovery4c03571a-93da-4504-8acf-c74326449852

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