Publication
Developmental expression of Shisa-2 in Xenopus laevis
| dc.contributor.author | Silva, Ana-Cristina | |
| dc.contributor.author | Filipe, Mario | |
| dc.contributor.author | Vitorino, Marta | |
| dc.contributor.author | Steinbeisser, Herbert | |
| dc.contributor.author | Belo, José A. | |
| dc.date.accessioned | 2018-12-07T14:58:37Z | |
| dc.date.available | 2018-12-07T14:58:37Z | |
| dc.date.issued | 2006 | |
| dc.description.abstract | Shisa is an antagonist of Wnt and FGF signaling, that functions cell autonomously in the endoplasmic reticulum (ER) to inhibit the post-translational maturation of Wnt and FGF receptors. In this paper we report the isolation of a second Xenopus shisa gene (Xshisa-2). Xenopus Shisa-2shows 30.7% identity to Xshisa. RT-PCR analysis indicated that Xshisa-2 mRNA is present throughout early development and shows an increased expression during neurula and tailbud stages. At neurula stages Xenopus shisa-2 is initially expressed in the presomitic paraxial mesoderm and later in the developing somites. The expression profiles and pattern of Xshisa and Xshisa-2 differ significantly. During gastrulation only Xshisa mRNA is present in the Spemann-Mangold organizer and later on becomes restricted to the neuroectoderm and the prechordal plate. | |
| dc.identifier.doi | 10.1387/ijdb.062141as | |
| dc.identifier.issn | 0214-6282 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/12125 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | UBC Press | |
| dc.subject | Head induction | |
| dc.subject | Mouse embryo | |
| dc.subject | Wnt | |
| dc.subject | Activation | |
| dc.subject | Cerberus | |
| dc.subject | Mesoderm | |
| dc.subject | Growth | |
| dc.subject | Somitogenesis | |
| dc.subject | Inhibition | |
| dc.subject | Somite | |
| dc.title | Developmental expression of Shisa-2 in Xenopus laevis | |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 579 | |
| oaire.citation.issue | 6 | |
| oaire.citation.startPage | 575 | |
| oaire.citation.title | International Journal of Developmental Biology | |
| oaire.citation.volume | 50 | |
| person.familyName | Vitorino | |
| person.familyName | Belo | |
| person.givenName | Marta | |
| person.givenName | José A. | |
| person.identifier.ciencia-id | 4615-FF5B-E951 | |
| person.identifier.ciencia-id | BF13-08E9-25E6 | |
| person.identifier.orcid | 0000-0001-8563-8975 | |
| person.identifier.orcid | 0000-0001-7384-0949 | |
| person.identifier.rid | U-9947-2018 | |
| person.identifier.rid | F-4444-2012 | |
| person.identifier.scopus-author-id | 6602141392 | |
| rcaap.rights | openAccess | |
| rcaap.type | article | |
| relation.isAuthorOfPublication | 94a8c9c7-6d95-40ac-805a-766e82851c62 | |
| relation.isAuthorOfPublication | 4bebeb48-6fac-41a9-8363-f849def5e019 | |
| relation.isAuthorOfPublication.latestForDiscovery | 94a8c9c7-6d95-40ac-805a-766e82851c62 |
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