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Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata

2020-10Journal article Restricted access
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dc.contributor.authorMello, Luiza Costa
dc.contributor.authorFonseca, Tainá
dc.contributor.authorde Souza, Abessa Denis Moledode
dc.date.accessioned2021-06-24T11:35:13Z
dc.date.available2021-06-24T11:35:13Z
dc.date.issued2020-10
dc.description.abstractThe consumption of anticancer agents has increased in the recent decades, and these substances may be present in sewage. Consequently, they may reach the environment when sanitation infrastructure is ineffective. This study evaluated the toxicity of three anticancer agents-Tamoxifen (TAM), Cisplatin (CisPt), and Cyclophosphamide (CP)-on the development of embryos of the sand-dollar Mellita quinquiesperforata. Adult individuals were collected in sandy beaches, and gametes were obtained. Freshly-fertilized eggs were exposed to increasing sets of concentrations of each compound, and the effective concentrations needed to cause a 50% effect in the organisms (EC50) were calculated. The three compounds were toxic, and their EC50 values were 16.78 +/- 2.42 ng.L-1 (TAM), 27.20 +/- 38.26 ng.L-1 (CisPt), and 101.82 +/- 70.96 ng.L-1 (CP). There is no information on the environmental levels of these compounds in Brazil, but as they were already detected in ng.L-1 levels worldwide, it can be expected that these substances pose environmental risks to the marine biota.
dc.description.sponsorshipSao Paulo Research Foundation - FAPESPFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [18/19123-9]
dc.description.sponsorshipBrazilian National Council for Scientific and Technological Development (CNPq), through the Science Without Borders ProgramConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [202360/2014-8]
dc.description.sponsorshipCNPqConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [308533/2018-6, 311609/2014-7]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.marpolbul.2020.111493
dc.identifier.issn0025-326X
dc.identifier.urihttp://hdl.handle.net/10400.1/16373
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.subjectPharmaceuticals
dc.subjectMarine pollution
dc.subjectChemotherapeutics
dc.subjectEcotoxicity
dc.subjectEchinoderms
dc.subject.otherEnvironmental Sciences & Ecology; Marine & Freshwater Biology
dc.titleEcotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMAR%2F00350%2F2013/PT
oaire.citation.startPage111493
oaire.citation.titleMarine Pollution Bulletin
oaire.citation.volume159
oaire.fundingStream5876
person.familyNameGARCIA DA FONSECA
person.givenNameTAINÁ
person.identifier.ciencia-idCC10-4E47-B6DD
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication0bacd985-5b3b-4cc8-a31c-774ec234205f
relation.isAuthorOfPublication.latestForDiscovery0bacd985-5b3b-4cc8-a31c-774ec234205f
relation.isProjectOfPublication3c9090f1-c8fc-4990-8cd8-d61d72eb13f7
relation.isProjectOfPublication.latestForDiscovery3c9090f1-c8fc-4990-8cd8-d61d72eb13f7

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