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The effect of Conjugated Linoleic Acid intake on oxidative stress parameters and antioxidant enzymes: A systematic review and meta-analysis of randomized clinical trials

2022Journal article Restricted access
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dc.contributor.authorMorvaridzadeh, Mojgan
dc.contributor.authorEstêvão, M. Dulce
dc.contributor.authorMorvaridi, Mehrnaz
dc.contributor.authorBelančić, Andrej
dc.contributor.authorMohammadi, Shooka
dc.contributor.authorHassani, Motahareh
dc.contributor.authorHeshmati, Javad
dc.contributor.authorZiaei, Somayeh
dc.date.accessioned2023-01-11T13:38:21Z
dc.date.available2023-01-11T13:38:21Z
dc.date.issued2022
dc.description.abstractConjugated Linoleic Acid (CLA) are thought to pose beneficial effects on inflammatory responses and oxidative stress (OS). Thus, the present systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to assess the net effects of CLA supplementation on various OS parameters and antioxidant enzymes. PubMed/ MEDLINE, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials databases were searched for publications on CLA supplementation effects on OS parameters up to March 2021. The data extracted from eligible studies were expressed as standardized mean difference with 95% confidence intervals and then combined into meta-analysis using the random-effects model. Overall, 11 RCTs (enrolling 586 participants) met the inclusion criteria and were included in meta-analysis; however, since those trials evaluated different OS parameters, meta-analysis was carried out considering different sets for each parameter separately. According to our results, CLA supplementation significantly increases 8-iso-PGF(2 alpha )urinary concentration (SMD: 2; 95% CI: 0.74, 3.27; I-2 = 87.7%). On contrary, the intervention does not seem to change 15-keto-dihydro-PGF(2 alpha )urinary concentration, nor the serum levels of CAT, SOD, GPx and MDA. Taken all together, CLA supplementation does not appear to have substantial effects on OS markers in general; albeit due to relatively small sample size and high level of heterogeneity between studies, the obtained findings should be interpreted with caution. Further large well-designed RCTs, investigating the impact of CLA and including various groups of patients, are still needed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.prostaglandins.2022.106666pt_PT
dc.identifier.eissn2212-196X
dc.identifier.urihttp://hdl.handle.net/10400.1/18794
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectConjugated linoleic acidpt_PT
dc.subjectOxidative stresspt_PT
dc.subject8-iso-PGF2apt_PT
dc.titleThe effect of Conjugated Linoleic Acid intake on oxidative stress parameters and antioxidant enzymes: A systematic review and meta-analysis of randomized clinical trialspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage106666pt_PT
oaire.citation.titleProstaglandins & Other Lipid Mediatorspt_PT
oaire.citation.volume163pt_PT
person.familyNameEstêvão
person.givenNameMaria Dulce da Mota Antunes de Oliveira
person.identifierI-4695-2014
person.identifier.ciencia-id881B-53E8-0DB1
person.identifier.orcid0000-0002-7151-8363
person.identifier.scopus-author-id8381590400
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication67887883-2695-48cc-8221-aa46780ac143
relation.isAuthorOfPublication.latestForDiscovery67887883-2695-48cc-8221-aa46780ac143

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