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Divergence of duplicate POMC genes in gilthead sea bream Sparus auratus

2011Journal article Restricted access
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dc.contributor.authorCardoso, João
dc.contributor.authorLaiz-Carrión, R.
dc.contributor.authorLouro, Bruno
dc.contributor.authorSilva, Nádia
dc.contributor.authorCanario, Adelino V. M.
dc.contributor.authorMancera, J. M.
dc.contributor.authorPower, Deborah
dc.date.accessioned2014-05-09T14:37:32Z
dc.date.available2014-05-09T14:37:32Z
dc.date.issued2011
dc.date.updated2014-05-08T09:56:11Z
dc.description.abstractProopiomelanocorticotrophin (POMC) in vertebrates is produced in the pituitary gland and undergoes post-translational processing to give rise to a range of biologically active peptides. Teleosts possess 2–3 different POMC transcripts which have been proposed to have originated from a whole or partial genome duplication. In the present study 2 transcripts of gilthead sea bream POMC (sbPOMC-a1 and a2) were cloned and characterised. sbPOMC-a1 is expressed principally in the melanotroph cells of the pars intermedia (PI) and sbPOMC-a2 is expressed in the corticotroph cells of the rostral pars distalis and probably also in the PI. The 2 sbPOMC transcripts have a differential tissue distribution in extra-pituitary sites. An appraisal of POMC evolution indicates sbPOMCs belong to one of the two main clades that exist in teleosts and that overall a non conservative process of gene loss occurred in this infraclass.por
dc.identifier.citationCardoso, J.C.R.; Laiz-Carrion, R.; Louro, B.; Silva, N.; Canario, A.V.M.; Mancera, J.M.; Power, D.M. Divergence of duplicate POMC genes in gilthead sea bream Sparus auratus, General and Comparative Endocrinology, 173, 3, 396-404, 2011.por
dc.identifier.doihttp://dx.doi.org/10.1016/j.ygcen.2010.12.001
dc.identifier.issn00166480
dc.identifier.otherAUT: ACA00258; DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/3833
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectEctopic expressionpor
dc.subjectEvolutionpor
dc.subjectGene duplicationpor
dc.subjectPituitarypor
dc.subjectPOMCpor
dc.subjectSub-functionalizationpor
dc.titleDivergence of duplicate POMC genes in gilthead sea bream Sparus auratuspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage404por
oaire.citation.issue3por
oaire.citation.startPage396por
oaire.citation.titleGeneral and Comparative Endocrinologypor
oaire.citation.volume173por
person.familyNameCardoso
person.familyNameLouro
person.familyNameSilva
person.familyNameCanario
person.familyNamePower
person.givenNameJoão
person.givenNameBruno
person.givenNameNádia
person.givenNameAdelino
person.givenNameDeborah Mary
person.identifier14332
person.identifier143624
person.identifier.ciencia-id8B16-F203-2AFC
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person.identifier.orcid0000-0001-9881-4421
person.identifier.orcid0000-0002-6244-6468
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id16028940200
person.identifier.scopus-author-id10244362100
person.identifier.scopus-author-id56568523700
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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