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Differential tissue immune stimulation through immersion in bacterial and viral agonists in the Antarctic Notothenia rossii

2024Journal article Open access
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dc.contributor.authorSousa, Carmen
dc.contributor.authorPeng, Maoxiao
dc.contributor.authorGuerreiro, Pedro
dc.contributor.authorCardoso, João
dc.contributor.authorChen, Liangbiao
dc.contributor.authorCanario, Adelino
dc.contributor.authorPower, Deborah
dc.date.accessioned2024-05-14T08:52:09Z
dc.date.available2024-05-14T08:52:09Z
dc.date.issued2024
dc.description.abstractThe genome evolution of Antarctic notothenioids has been modulated by their extreme environment over millennia and more recently by human -caused constraints such as overfishing and climate change. Here we investigated the characteristics of the immune system in Notothenia rossii and how it responds to 8 h immersion in viral (Poly I:C, polyinosinic: polycytidylic acid) and bacterial (LPS, lipopolysaccharide) proxies. Blood plasma antiprotease activity and haematocrit were reduced in Poly I:C-treated fish only, while plasma protein, lysozyme activity and cortisol were unchanged with both treatments. The skin and duodenum transcriptomes responded strongly to the treatments, unlike the liver and spleen which had a mild response. Furthermore, the skin transcriptome responded most to the bacterial proxy (cell adhesion, metabolism and immune response processes) and the duodenum (metabolism, response to stress, regulation of intracellular signal transduction, and immune system responses) to the viral proxy. The differential tissue response to the two proxy challenges is indicative of immune specialisation of the duodenum and the skin towards pathogens. NOD -like and C -type lectin receptors may be central in recognising LPS and Poly I:C. Other antimicrobial compounds such as iron and seleniumrelated genes are essential defence mechanisms to protect the host from sepsis. In conclusion, our study revealed a specific response of two immune barrier tissue, the skin and duodenum, in Notothenia rossii when exposed to pathogen proxies by immersion, and this may represent an adaptation to pathogen infective strategies.pt_PT
dc.description.sponsorshipEMBRC.PT ALG-01-0145-FEDER-022121; BIODATA.PT ALG-01-0145-FEDER-022231; PROPOLAR2016;pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.fsi.2024.109516pt_PT
dc.identifier.issn1050-4648
dc.identifier.urihttp://hdl.handle.net/10400.1/20722
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationCentre for Marine and Environmental Research
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNototheniidaept_PT
dc.subjectEndotoxinpt_PT
dc.subjectImmune systempt_PT
dc.subjectTranscriptomept_PT
dc.subjectViral stimulipt_PT
dc.titleDifferential tissue immune stimulation through immersion in bacterial and viral agonists in the Antarctic Notothenia rossiipt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F120040%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/NSFC%2F0002%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2014/PTDC%2FBIA-ANM%2F3484%2F2014/PT
oaire.citation.startPage109516pt_PT
oaire.citation.titleFish & Shellfish Immunologypt_PT
oaire.citation.volume148pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStreamProjetos de Investigação Científica e Desenvolvimento Tecnológico - 2014
person.familyNameVieira de Sousa
person.familyNamePeng
person.familyNameGuerreiro da Costa Guerreiro
person.familyNameCardoso
person.familyNameCanario
person.familyNamePower
person.givenNameCármen Sofia
person.givenNameMaoxiao
person.givenNamePedro Miguel
person.givenNameJoão
person.givenNameAdelino
person.givenNameDeborah Mary
person.identifierA-2539-2009
person.identifier14332
person.identifier143624
person.identifier.ciencia-idE511-2F93-F25D
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person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-3483-1932
person.identifier.orcid0000-0002-4855-1202
person.identifier.orcid0000-0001-5371-7919
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0002-6244-6468
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id56568523700
person.identifier.scopus-author-id7101806760
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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