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An integrative review of potential diagnostic biomarkers for complex regional pain syndrome

2025-05-27Journal article Open access
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dc.contributor.authorLopes, Revelino
dc.contributor.authorSantos, André
dc.contributor.authorGomes, Teresa
dc.contributor.authorRibeiro, Júlia
dc.contributor.authorRodrigues, Ivone
dc.contributor.authorPaiva, Bruno
dc.contributor.authorNzwalo, Isa
dc.contributor.authorCatamo Vaz, Deise Haua da Silva
dc.contributor.authorBaco, Jamal
dc.contributor.authorBuque, Helena Agostinho
dc.contributor.authorBotelho, Marta
dc.contributor.authorPais, Sandra
dc.contributor.authorNzwalo, Hipólito
dc.date.accessioned2025-07-21T09:16:14Z
dc.date.available2025-07-21T09:16:14Z
dc.date.issued2025-05-27
dc.description.abstractBackground: Complex regional pain syndrome (CRPS) is a rare, chronic, painful, neurological, debilitating disorder. Despite the substantial impact on quality of life, diagnosis remains challenging due to its complex pathophysiology and subjective clinical criteria. This integrative review aims to synthesize current research on potential diagnostic biomarkers for CRPS. Methods: A systematic search was conducted using the PubMed and Scopus databases to identify relevant studies published until January 2025. Inclusion criteria focused on adult CRPS patients, with studies examining diagnostic or predictive biomarkers. Results: Key findings highlight the role of inflammatory and immune-related biomarkers, such as elevated levels of cytokines (IL-6, TNF-alpha), immune cell infiltration, and specific autoantibodies. Neuropeptides, including substance P and calcitonin gene-related peptide, were associated with pain sensitization in acute phases, though their levels normalized in chronic stages. Additionally, genetic and epigenetic markers, brain imaging, and neurophysiological alterations provided insights into CRPS pathogenesis, emphasizing the dynamic nature of these biomarkers across disease stages. Conclusions: This review underscores the need for further research to integrate these biomarkers into diagnostic frameworks, which could enhance early diagnosis and treatment strategies for CRPS.eng
dc.identifier.doi10.3390/jcm14113751
dc.identifier.issn2077-0383
dc.identifier.urihttp://hdl.handle.net/10400.1/27465
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.ispartofJournal of Clinical Medicine
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectComplex regional pain syndrome
dc.subjectBiomarkers
dc.subjectCytokines
dc.subjectNeuropeptides
dc.subjectInflammation
dc.subjectImmune response
dc.titleAn integrative review of potential diagnostic biomarkers for complex regional pain syndromeeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11
oaire.citation.startPage3751
oaire.citation.titleJournal of Clinical Medicine
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameNzwalo
person.familyNameCatamo Vaz
person.familyNameBuque
person.familyNameBotelho
person.familyNameNzwalo
person.givenNameIsa
person.givenNameDeise Haua da Silva
person.givenNameHelena Agostinho
person.givenNameMarta
person.givenNameHipólito
person.identifier337064
person.identifier.ciencia-idE11E-315B-E8F5
person.identifier.ciencia-id7D1E-BCB3-86E1
person.identifier.ciencia-id4A16-BDAB-AF45
person.identifier.ciencia-id2C1F-E4F3-2C79
person.identifier.orcid0000-0003-0929-4212
person.identifier.orcid0000-0003-0359-9904
person.identifier.orcid0000-0001-9589-4446
person.identifier.orcid0000-0002-1502-3534
person.identifier.ridAAG-3931-2020
person.identifier.scopus-author-id57150464000
person.identifier.scopus-author-id36057285600
relation.isAuthorOfPublication447433fe-8230-415c-83e2-4d4cccc5da88
relation.isAuthorOfPublication130098f7-926d-4028-8822-e06d032859c9
relation.isAuthorOfPublication65ccebaf-c51c-4f0a-8cd3-2e24482fc570
relation.isAuthorOfPublicationb9a44af4-bd61-4609-a6ee-870e48f59682
relation.isAuthorOfPublication287f7d4e-5ad8-4794-b526-c61d32c00446
relation.isAuthorOfPublication.latestForDiscovery130098f7-926d-4028-8822-e06d032859c9

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