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Olmesartan-induced enteropathy: an unusual cause of villous atrophy

2016-04Journal article Open access
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dc.contributor.authorEusébio, Marta
dc.contributor.authorCaldeira, Paulo
dc.contributor.authorAntunes, Artur GiĂŁo
dc.contributor.authorRamos, André
dc.contributor.authorVelasco, Francisco
dc.contributor.authorCadill, JesĂșs
dc.contributor.authorGuerreiro, Horacio
dc.date.accessioned2017-04-07T15:56:46Z
dc.date.available2017-04-07T15:56:46Z
dc.date.issued2016-04
dc.description.abstractWe report a case of a 63-year-old-man presenting with chronic diarrhea and weight loss while on olmesartan treatment for hypertension. Investigation showed multiple nutritional deficiencies associated with diffuse intestinal villous atrophy. Serologies for celiac disease were negative and other causes of villous atrophy were excluded. Olmesartan as a precipitant agent was suspected and withdrawn. Clinical improvement occurred in days with no need for other therapeutic measures. Follow-up at three months showed clinical remission and almost complete recovery of intestinal atrophy. Olmesartan is an angiotensin receptor blocker commonly prescribed for the management of hypertension. Spruelike enteropathy associated with this drug is a recently described entity with few cases reported. It presents with chronic diarrhea and intestinal villous atrophy and should be included in its differential diagnosis. This case intends to alert clinicians for the possibility of this event in a patient on treatment with this drug.
dc.description.abstractApresentamos o caso de um homem de 63 anos com diarreia crĂłnica e perda ponderal. Apresentava hipertensĂŁo arterial tratada com olmesartan. A investigacžão complementar mostrou mĂșltiplos dĂ©fices nutricionais associados a atrofia vilositĂĄria intestinal difusa. As serologias de doença celĂ­aca foram negativas e outras causas de atrofia vilositĂĄria foram excluĂ­das. Suspeitou-se do olmesartan como agente precipitante, sendo este suspenso. Observou-se melhoria clĂ­nica em dias, sem necessidade de outras medidas terapĂȘuticas. No seguimento, aos 3 meses, constatou-se remissĂŁo clĂ­nica e recuperação quase completa da atrofia intestinal. O olmesartan Ă© um bloqueador dos recetores da angiotensina, geralmente prescrito no tratamento da hipertensĂŁo. A enteropatia ‘‘spruelike’’ associada a este fĂĄrmaco Ă© uma entidade recentemente descrita, com poucos casos reportados. Manifesta-se por diarreia crĂłnica associada a atrofia vilositĂĄria intestinal, devendo ser incluĂ­da no seu diagnĂłstico diferencial. Com este caso pretende-se alertar os clĂ­nicos para a possibilidade deste evento em doentes sob tratamento com este fĂĄrmaco.
dc.identifier.doihttp://dx.doi.org/10.1016/j.jpge.2015.09.005
dc.identifier.issn2341-4545
dc.identifier.urihttp://hdl.handle.net/10400.1/9518
dc.language.isoeng
dc.peerreviewedyes
dc.publisherKarger Publishers Open Access
dc.relation.isbasedonSCIELO:S2341-45452016000200006
dc.subjectAtrophy
dc.subjectGastrointestinal diseases
dc.subjectAngiotensin II receptor antagonist/adverse effects
dc.subjectAtrofia
dc.subjectDoenças gastrointestinais
dc.titleOlmesartan-induced enteropathy: an unusual cause of villous atrophy
dc.title.alternativeEnteropatia induzida pelo olmesartan: uma causa incomum de atrofia vilositĂłria
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage95
oaire.citation.issue2
oaire.citation.startPage91
oaire.citation.titleGE-Portuguese Journal of Gastroenterology
oaire.citation.volume23
person.familyNameEusébio
person.familyNameCaldeira
person.familyNameGuerreiro
person.givenNameMarta
person.givenNamePaulo
person.givenNameHoracio
person.identifier.ciencia-id1112-F0B2-19A3
person.identifier.orcid0000-0002-3529-7241
person.identifier.orcid0000-0002-2404-6295
person.identifier.orcid0000-0002-1387-5813
person.identifier.scopus-author-id57188667152
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication55317087-428e-4613-af6b-571fefc96f5a
relation.isAuthorOfPublication3def3720-8982-4c46-801d-af640d508b59
relation.isAuthorOfPublication76efcc1f-bb58-4a5b-b4f5-9f206622df4f
relation.isAuthorOfPublication.latestForDiscovery76efcc1f-bb58-4a5b-b4f5-9f206622df4f

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