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GABA receptors in the olfactory epithelium of the gilthead seabream (Sparus aurata)

2022Journal article Restricted
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dc.contributor.authorCosta, Rita
dc.contributor.authorVelez, Zélia
dc.contributor.authorHubbard, Peter
dc.date.accessioned2022-02-15T15:24:55Z
dc.date.available2023-01-01T01:30:13Z
dc.date.issued2022
dc.description.abstractExposure to high PCO2/low pH seawater induces behavioural alterations in fish; a possible explanation for this is a reversal of Cl-/HCO3- currents through GABAA receptors (the GABAA receptor theory). However, the main evidence for this is that gabazine, a GABAA receptor antagonist, reverses these effects when applied to the water, assuming that exposure to systems other than the CNS would be without effect. Here, we show the expression of both metabotropic and ionotropic GABA receptors, and the presence of GABAA receptor protein, in the olfactory epithelium of gilthead seabream. Furthermore, exposure of the olfactory epithelium to muscimol (a specific GABAA receptor agonist) increases or decreases the apparent olfactory sensitivity to some odorants. Thus, although the exact function of GABAA receptors in the olfactory epithelium is not yet clear, this may complicate the interpretation of studies wherein water-borne gabazine is used to reverse the effects of high CO2 levels on olfactory-driven behaviour in fish.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1242/jeb.243112pt_PT
dc.identifier.issn0022-0949
dc.identifier.urihttp://hdl.handle.net/10400.1/17558
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe Company of Biologistspt_PT
dc.subjectGABA receptorspt_PT
dc.subjectOlfactory epitheliumpt_PT
dc.titleGABA receptors in the olfactory epithelium of the gilthead seabream (Sparus aurata)pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-BMA%2F30262%2F2017/PT
oaire.citation.issue3pt_PT
oaire.citation.titleJournal of Experimental Biologypt_PT
oaire.citation.volume225pt_PT
oaire.fundingStream9471 - RIDTI
person.familyNameCosta
person.familyNameVelez
person.familyNameHubbard
person.givenNameRita
person.givenNameZélia
person.givenNamePeter
person.identifier.ciencia-id8219-DFF3-929F
person.identifier.ciencia-id4412-F95B-34A2
person.identifier.ciencia-id951F-BA4B-A21F
person.identifier.orcid0000-0002-6975-7576
person.identifier.orcid0000-0003-2761-4048
person.identifier.orcid0000-0002-3007-4647
person.identifier.ridO-9136-2018
person.identifier.ridM-5283-2013
person.identifier.ridB-2823-2008
person.identifier.scopus-author-id57097731700
person.identifier.scopus-author-id16176444400
person.identifier.scopus-author-id7005928467
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication943d1248-7839-42b3-89a9-b539b3209cd7
relation.isAuthorOfPublication3292b0fd-8d08-4512-b512-a04b31a7926a
relation.isAuthorOfPublicationf599b3ac-806b-4f65-9eb6-f70e68bcb142
relation.isAuthorOfPublication.latestForDiscoveryf599b3ac-806b-4f65-9eb6-f70e68bcb142
relation.isProjectOfPublication16d709b4-9fad-4113-a9b3-ce47179b5107
relation.isProjectOfPublication.latestForDiscovery16d709b4-9fad-4113-a9b3-ce47179b5107

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