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Vitamin K as a diet supplement with impact in human health: current evidence in age-related idseases

2020Journal article Open access
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dc.contributor.authorSimes, Dina
dc.contributor.authorViegas, Carla
dc.contributor.authorAraujo, Nuna C. P.
dc.contributor.authorMarreiros, Catarina
dc.date.accessioned2020-03-30T14:15:24Z
dc.date.available2020-03-30T14:15:24Z
dc.date.issued2020
dc.description.abstractVitamin K health benefits have been recently widely shown to extend beyond blood homeostasis and implicated in chronic low-grade inflammatory diseases such as cardiovascular disease, osteoarthritis, dementia, cognitive impairment, mobility disability, and frailty. Novel and more efficient nutritional and therapeutic options are urgently needed to lower the burden and the associated health care costs of these age-related diseases. Naturally occurring vitamin K comprise the phylloquinone (vitamin K1), and a series of menaquinones broadly designated as vitamin K2 that differ in source, absorption rates, tissue distribution, bioavailability, and target activity. Although vitamin K1 and K2 sources are mainly dietary, consumer preference for diet supplements is growing, especially when derived from marine resources. The aim of this review is to update the reader regarding the specific contribution and effect of each K1 and K2 vitamers in human health, identify potential methods for its sustainable and cost-efficient production, and novel natural sources of vitamin K and formulations to improve absorption and bioavailability. This new information will contribute to foster the use of vitamin K as a health-promoting supplement, which meets the increasing consumer demand. Simultaneously, relevant information on the clinical context and direct health consequences of vitamin K deficiency focusing in aging and age-related diseases will be discussed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/nu12010138pt_PT
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10400.1/13663
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationNot Available
dc.relationCentre of Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectVitamin Kpt_PT
dc.subjectInflammationpt_PT
dc.subjectDiet supplementpt_PT
dc.subjectAge-related diseasespt_PT
dc.subjectVitamin K-dependent proteinspt_PT
dc.subjectPathological calcificationpt_PT
dc.titleVitamin K as a diet supplement with impact in human health: current evidence in age-related idseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNot Available
oaire.awardTitleCentre of Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL 57%2F2016%2FCP1361%2FCT0006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04326%2F2019/PT
oaire.citation.issue1pt_PT
oaire.citation.startPage138pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStreamDL 57/2016
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSimes
person.familyNameViegas
person.familyNameAraujo
person.familyNameMARREIROS
person.givenNameDina
person.givenNameCarla
person.givenNameNuna
person.givenNameCATARINA
person.identifier.ciencia-idC414-F596-EEC6
person.identifier.ciencia-idB116-E70E-EB2A
person.identifier.orcid0000-0002-5145-4753
person.identifier.orcid0000-0002-5765-3665
person.identifier.orcid0000-0002-7602-0150
person.identifier.ridN-2789-2014
person.identifier.ridN-6695-2014
person.identifier.ridN-8531-2013
person.identifier.scopus-author-id7201884723
person.identifier.scopus-author-id8656310300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication33984b3c-ffac-477a-896a-ddbf7aced4e3
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