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ceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiation

2022Journal article Open access
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dc.contributor.authorTang, Lili
dc.contributor.authorHuang, Fei
dc.contributor.authorYou, Wuxin
dc.contributor.authorPoetsch, Ansgar
dc.contributor.authorNóbrega, Rafael Henrique
dc.contributor.authorPower, Deborah
dc.contributor.authorZhu, Tengfei
dc.contributor.authorLiu, Kaiqiang
dc.contributor.authorWang, Hong-Yan
dc.contributor.authorWang, Qian
dc.contributor.authorXu, Xiwen
dc.contributor.authorFeng, Bo
dc.contributor.authorSchartl, Manfred
dc.contributor.authorShao, Changwei
dc.date.accessioned2023-01-10T14:09:18Z
dc.date.available2023-01-10T14:09:18Z
dc.date.issued2022
dc.description.abstractCompeting endogenous RNAs (ceRNAs) are vital regulators of gene networks in mammals. The involvement of noncoding RNAs (ncRNAs) as ceRNA in genotypic sex determination (GSD) and environmental sex determination (ESD) in fish is unknown. The Chinese tongue sole, which has both GSD and ESD mechanisms, was used to map the dynamic expression pattern of ncRNAs and mRNA in gonads during sex determination and differentiation. Transcript expression patterns shift during the sex differentiation phase, and ceRNA modulation occurs through crosstalk of differentially expressed long ncRNAs (lncRNAs), circular RNAs (circRNAs), microRNAs (miRNAs), and sex-related genes in fish. Of note was the significant up-regulation of a circRNA from the sex-determining gene dmrt1 (circular RNA dmrt1) and a lncRNA, called AMSDT (which stands for associated with male sex differentiation of tongue sole) in Chinese tongue sole testis. These two ncRNAs both share the same miRNA response elements with gsdf, which has an up-regulated expression when they bind to miRNA cse-miR-196 and concurrent down-regulated female sex-related genes to facilitate testis differentiation. This is the first demonstration in fish that ceRNA crosstalk mediated by ncRNAs modulates sexual development and unveils a novel regulatory mechanism for sex determination and differentiation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1101/gr.275962.121pt_PT
dc.identifier.eissn1549-5469
dc.identifier.urihttp://hdl.handle.net/10400.1/18783
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCold Spring Harbor Laboratory Presspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectDetermining genept_PT
dc.subjectPRP8 proteinpt_PT
dc.subjectDMRT1pt_PT
dc.subjectMedakapt_PT
dc.subjectChromosomept_PT
dc.subjectPlasticitypt_PT
dc.subjectDiversitypt_PT
dc.subjectEvolutionpt_PT
dc.subjectInsightspt_PT
dc.subjectRolespt_PT
dc.titleceRNA crosstalk mediated by ncRNAs is a novel regulatory mechanism in fish sex determination and differentiationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1515pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1502pt_PT
oaire.citation.titleGenome Researchpt_PT
oaire.citation.volume32pt_PT
person.familyNamePower
person.givenNameDeborah Mary
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0003-1366-0246
person.identifier.scopus-author-id7101806760
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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