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Systematic review of the application of perinatal derivatives in animal models on cutaneous wound healing

2021-09Journal article Open access
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dc.contributor.authorPichlsberger, Melanie
dc.contributor.authorJerman, Urška Dragin
dc.contributor.authorObradović, Hristina
dc.contributor.authorTratnjek, Larisa
dc.contributor.authorMacedo, Ana Sofia
dc.contributor.authorMendes, Francisca
dc.contributor.authorFonte, Pedro
dc.contributor.authorHoegler, Anja
dc.contributor.authorSundl, Monika
dc.contributor.authorFuchs, Julia
dc.contributor.authorSchoeberlein, Andreina
dc.contributor.authorKreft, Mateja Erdani
dc.contributor.authorMojsilović, Slavko
dc.contributor.authorLang-Olip, Ingrid
dc.date.accessioned2021-10-29T14:48:34Z
dc.date.available2021-10-29T14:48:34Z
dc.date.issued2021-09
dc.description.abstractKnowledge of the beneficial effects of perinatal derivatives (PnD) in wound healing goes back to the early 1900s when the human fetal amniotic membrane served as a biological dressing to treat burns and skin ulcerations. Since the twenty-first century, isolated cells from perinatal tissues and their secretomes have gained increasing scientific interest, as they can be obtained non-invasively, have anti-inflammatory, anti-cancer, and anti-fibrotic characteristics, and are immunologically tolerated in vivo. Many studies that apply PnD in pre-clinical cutaneous wound healing models show large variations in the choice of the animal species (e.g., large animals, rodents), the choice of diabetic or non-diabetic animals, the type of injury (full-thickness wounds, burns, radiation-induced wounds, skin flaps), the source and type of PnD (placenta, umbilical cord, fetal membranes, cells, secretomes, tissue extracts), the method of administration (topical application, intradermal/ subcutaneous injection, intravenous or intraperitoneal injection, subcutaneous implantation), and the type of delivery systems (e.g., hydrogels, synthetic or natural biomaterials as carriers for transplanted cells, extracts or secretomes). This review provides a comprehensive and integrative overview of the application of PnD in wound healing to assess its efficacy in preclinical animal models. We highlight the advantages and limitations of the most commonly used animal models and evaluate the impact of the type of PnD, the route of administration, and the dose of cells/secretome application in correlation with the wound healing outcome. This review is a collaborative effort from the COST SPRINT Action (CA17116), which broadly aims at approaching consensus for different aspects of PnD research, such as providing inputs for future standards for the preclinical application of PnD in wound healing .pt_PT
dc.description.sponsorshipCOPA J56C18001930006; 451-03-9/2021-14/200015; J7-2594
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fbioe.2021.742858pt_PT
dc.identifier.issn2296-4185
dc.identifier.urihttp://hdl.handle.net/10400.1/17269
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relation17116pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPerinatal derivativespt_PT
dc.subjectPlacentapt_PT
dc.subjectCellspt_PT
dc.subjectPreclinical studiespt_PT
dc.subjectAnimal modelspt_PT
dc.subjectWound healingpt_PT
dc.subjectSkinpt_PT
dc.subjectCutaneouspt_PT
dc.titleSystematic review of the application of perinatal derivatives in animal models on cutaneous wound healingpt_PT
dc.title.alternativeRevisão sistemática da aplicação de derivados perinatais em modelos animais em cicatriz cutâneapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Bioengineering and Biotechnologypt_PT
oaire.citation.volume9pt_PT
person.familyNameFonte
person.givenNamePedro
person.identifier.ciencia-id2410-123D-3385
person.identifier.orcid0000-0002-1115-9282
person.identifier.ridK-3215-2013
person.identifier.scopus-author-id55146900200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa5a5c2b2-9112-4bf4-8618-8c2051bbc116
relation.isAuthorOfPublication.latestForDiscoverya5a5c2b2-9112-4bf4-8618-8c2051bbc116

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