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Ecotoxicity of emerging contaminants in the reproductive organ of marine mussels mytilus galloprovincialis

2023Journal article Open access
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dc.contributor.authorGonçalves, Joanna M.
dc.contributor.authorBebianno, M.
dc.date.accessioned2023-06-05T10:28:39Z
dc.date.available2023-06-05T10:28:39Z
dc.date.issued2023
dc.description.abstractContaminants of emerging concern (CECs) present a new threat to the marine environment, and it is vital to under-stand the interactions and possible toxicity of CEC mixtures once they reach the ocean. CECs-such as metal nanopar-ticles, nanoplastics, and pharmaceuticals-are groups of contaminants some of which have been individually evaluated, though their interactions as mixtures are still not fully understood. To ensure a healthy and prosperous fu-ture generation, successful reproduction is key: however, if hindered, population dynamics may be at danger leading to a negative impact on biodiversity. This study aimed to understand the effects of silver (20 nm nAg, 10 mu g/L), polysty-rene nanoparticles (50 nm nPS, 10 mu g/L), and 5-fluorouracil (5FU, 10 ng/L) individually and as a mixture (10 mu g/L of nPS + 10 mu g/L of nAg +10 ng/L of 5FU) in the gonads of Mytilus galloprovincialis. A multibiomarker approach, namely the antioxidant defence system (ADS; superoxide dismutase, catalase, glutathione peroxidases, glutathione - S - trans-ferases activities), and oxidative damage (OD; lipid peroxidation) were analysed in the gonads of mussels. All exposure treatments after 3 days led to an increase of enzymatic activity, followed by an inhibition after 14 and 21 days. Thus, ADS was overwhelmed due to the generation of ROS, resulting in OD, except for nPS exposed mussels. The OD in Mix exposed mussels increased exponentially by 57-fold. When CEC mixtures interact, they are potentially more hazardous than their individual components, posing a major threat to marine species. To understand synergistic and antagonistic interactions, a model was applied, and antagonistic interactions were observed in evaluated biomarkers at all time-points, apart from a synergistic interaction at day 3 relative to LPO. Results indicate that the effects observed in Mix-exposed mussel gonads are mainly due to the interaction of nAg and 5FU but not nPS.pt_PT
dc.description.sponsorshipJPIOCEANS/0005/2020; ALG-01-0145-FEDER-030922; LA/P/0069/2020pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.scitotenv.2023.163486pt_PT
dc.identifier.issn0048-9697
dc.identifier.urihttp://hdl.handle.net/10400.1/19661
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationEmerging: Environmental Mixtures of Emerging contaminants Repercussions on Gonads and Impact on Next Generations
dc.relationEfeitos de mixturas de contaminantes emergentes nos ecossistemas aquáticos: uma abordagem a vários níveis de organização biológica
dc.relationCentre for Marine and Environmental Research (CIMA)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCECspt_PT
dc.subjectM. galloprovincialispt_PT
dc.subject5-Fluorouracilpt_PT
dc.subjectSilver nanoparticlespt_PT
dc.subjectPolystyrene nanoplasticspt_PT
dc.subjectMixturept_PT
dc.titleEcotoxicity of emerging contaminants in the reproductive organ of marine mussels mytilus galloprovincialispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEmerging: Environmental Mixtures of Emerging contaminants Repercussions on Gonads and Impact on Next Generations
oaire.awardTitleEfeitos de mixturas de contaminantes emergentes nos ecossistemas aquáticos: uma abordagem a vários níveis de organização biológica
oaire.awardTitleCentre for Marine and Environmental Research (CIMA)
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F150758%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-BMA%2F30922%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00350%2F2020/PT
oaire.citation.startPage163486pt_PT
oaire.citation.titleScience of The Total Environmentpt_PT
oaire.citation.volume881pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRibeiro Gonçalves
person.familyNameBebianno
person.givenNameJoanna Melissa
person.givenNameMaria
person.identifier.ciencia-id2D1D-F33A-FB48
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0002-3242-1032
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
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