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Are Chinese consumers at risk due to exposure to metals in crayfish? A bioaccessibility-adjusted probabilistic risk assessment

2016-07Journal article Open access
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dc.contributor.authorPeng, Qian
dc.contributor.authorNunes, Luís
dc.contributor.authorGreenfield, Ben K.
dc.contributor.authorDang, Fei
dc.contributor.authorZhong, Huan
dc.date.accessioned2017-04-07T15:57:03Z
dc.date.available2017-04-07T15:57:03Z
dc.date.issued2016-07
dc.description.abstractFreshwater crayfish, the world's third largest crustacean species, has been reported to accumulate high levels of metals, while the current knowledge of potential risk associated with crayfish consumption lags behind that of finfish. We provide the first estimate of human health risk associated with crayfish (Procambarus clarkii) consumption in China, the world's largest producer and consumer of crayfish. We performed Monte Carlo Simulation on a standard risk model parameterized with local data on metal concentrations, bioaccessibility (phi), crayfish consumption rate, and consumer body mass. Bioaccessibility of metals in crayfish was found to be variable (68-95%) and metal-specific, suggesting a potential influence of metal bioaccessibility on effective metal intake. However, sensitivity analysis suggested risk of metals via crayfish consumption was predominantly explained by consumption rate (explaining >92% of total risk estimate variability), rather than metals concentration, bioaccessibility, or body mass. Mean metal concentrations (As, Cd, Cu, Ni, Pb, Se and Zn) in surveyed crayfish samples from 12 provinces in China conformed to national safety standards. However, risk calculation of phi-modified hazard quotient (HQ) and hazard index (HI) suggested that crayfish metals may pose a health risk for very high rate consumers, with a HI of over 24 for the highest rate consumers. Additionally, the phi-modified increased lifetime risk (ILTR) for carcinogenic effects due to the presence of As was above the acceptable level (10(-5)) for both the median (ILTR = 2.5 x 10(-5)) and 90th percentile (ILTR = 1.8 x 10(-4)), highlighting the relatively high risk of As in crayfish. Our results suggest a need to consider crayfish when assessing human dietary exposure to metals and associated health risks, especially for high crayfish-consuming populations, such as in China, USA and Sweden.
dc.description.sponsorshipHZ by the National Natural Science Foundation of China (41273087). LN was supported by European Union Marie Curie Actions, Grant FP People 2010 “IRSES Electroacross” and BG by the SAGE-IGERT Fellowship (US National Science Foundation).
dc.identifier.doi10.1016/j.envint.2015.12.035
dc.identifier.issn0160-4120
dc.identifier.urihttp://hdl.handle.net/10400.1/9597
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.isbasedonWOS:000371359300033
dc.subjectMetal
dc.subjectCrayfish
dc.subjectHuman health risk assessment
dc.subjectUncertainty
dc.subjectSensitivity
dc.titleAre Chinese consumers at risk due to exposure to metals in crayfish? A bioaccessibility-adjusted probabilistic risk assessment
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage268
oaire.citation.startPage261
oaire.citation.titleEnvironment International
oaire.citation.volume88
person.familyNameNunes
person.givenNameLuís
person.identifier93800
person.identifier.ciencia-id3112-1FCD-6685
person.identifier.orcid0000-0001-5606-970X
person.identifier.ridM-4647-2013
person.identifier.scopus-author-id7102529511
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationd32d0ac6-6cb6-4f03-afcf-3c80978d469f
relation.isAuthorOfPublication.latestForDiscoveryd32d0ac6-6cb6-4f03-afcf-3c80978d469f

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