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Reinfection incidence following surgical intervention for infected aortic bypass: a meta-analysis

2025-11-08Journal article Open access
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dc.contributor.authorBrazuna, Márcio
dc.contributor.authorCosta, Marta Gonçalves
dc.contributor.authorMarreiros, Ana
dc.contributor.authorAndrade, Leonardo Araújo
dc.contributor.authorAndrade, José Paulo
dc.contributor.authorNeves, João Rocha
dc.date.accessioned2025-12-17T11:57:55Z
dc.date.available2025-12-17T11:57:55Z
dc.date.issued2025-11-08
dc.description.abstractBackground Infection of vascular grafts after aortic revascularization surgery is a serious complication with high morbid ity and mortality. This systematic review and meta-analysis aims to determine reinfection incidence in patients undergoing surgical intervention for infected aortic bypass grafts and identify key risk factors in the literature. Materials and Methods This systematic review and meta-analysis followed PRISMA guidelines. Three electronic databases, PubMed/MEDLINE, Scopus, and Web of Science were used to search studies published after January 1, 2000, that assessed reinfection rates following surgical intervention for infected aortic bypass grafts. Random-effects meta-analysis was per formed to calculate pooled incidence of major outcomes.Results: Our systematic review included 30 studies with a total of 2,341 patients. Overall reinfection rate was 12.7% (95% CI: 8.6%–16.9%). In terms of morbidity 34.1% had acute kidney injury, 23.8% needed amputation, and 29.4% developed acute limb ischemia. The 30-day mortality rate was 27.8% (95% CI: 13.2%–42.4%).The medical approach to treatment varied significantly, however, the majority involved total removal of the infected prosthesis. The main microorganisms isolated in primary infections were mostly Staphylococcus and Enterococ cus species, with a notable representation of gram-negative bacteria.Conclusion: Reinfection rates after surgical treatment of infected aortic bypass grafts were relatively high and constitute a challenge of high clinical impact. This is further demon strated by the high 30-day mortality rate. The significant variation in treatment approaches observed above also highlights the lack of formalized management protocols. Further studies are needed to determine the best surgical approach and patientrelated risk factors to optimize outcomes in this difficult population.eng
dc.identifier.doi10.1007/s10096-025-05248-9
dc.identifier.eissn1435-4373
dc.identifier.issn0934-9723
dc.identifier.urihttp://hdl.handle.net/10400.1/27973
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.relationResearch Centre for Tourism, Sustainability and Well-being
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseases
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectVascular Grafting
dc.subjectAdverse effects
dc.subjectProsthesis-related infections
dc.subjectAortic Diseases / surgery
dc.subjectVascular graft infection
dc.subjectBiofilms
dc.subjectNosocomial infection
dc.titleReinfection incidence following surgical intervention for infected aortic bypass: a meta-analysiseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleResearch Centre for Tourism, Sustainability and Well-being
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04020%2F2020/PT
oaire.citation.titleEuropean Journal of Clinical Microbiology and Infectious Diseases
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBrazuna
person.familyNameMarreiros
person.givenNameMárcio
person.givenNameAna
person.identifier.ciencia-id9A12-9450-7051
person.identifier.orcid0009-0004-2710-0738
person.identifier.orcid0000-0001-9410-4772
person.identifier.scopus-author-id57194785077
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication76b5049d-c632-4b26-9568-8ef2b035abd4
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relation.isAuthorOfPublication.latestForDiscoveryc0a8e5da-26ae-42a8-ab04-fa4df4356375
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relation.isProjectOfPublication.latestForDiscoveryfa579efb-63c0-486e-b05d-859542b73647

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