Publication
Intermediate filaments are natural energy conductors in live cells
| dc.contributor.author | Khmelinskii, Igor | |
| dc.contributor.author | Makarov, Vladimir | |
| dc.date.accessioned | 2022-12-19T10:21:55Z | |
| dc.date.available | 2022-12-19T10:21:55Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Two possible mechanisms describing intra-and inter-cell energy transfer in biological systems were analyzed. The first one is based on Davydov vibration soliton (DVS) theory, implying C=O vibrational energy transfer along alpha-helix polypeptides. According to Davydov, a certain vibration of one of the C=O groups somehow receives the entirety of ATP hydrolysis energy within an enzyme molecule. Next, dipole-dipole interactions of the C=O groups of neighboring amino acid residues should ensure propagation of the DVS along the polypeptide chain, transporting it to the site of catalytic reaction. Strong limitations of this theory when applied to energy transfer in living systems were underlined, accompanied by total lack of experimental evidence of DVS existence. The second, much more viable mechanism, based on electronic excited state (exciton) propagation along individual protein molecules and their assemblies - intermediate filaments (IFs) - was considered and discussed in detail. Excitons in IFs may be generated by photon absorption or by ATP hydrolysis energy transfer to IFs. Infrared (IR) excitons were generated in the latter case, which propagated along IFs, enabling energy transfer within and between cells, and inter-cellular communications. Earlier is has been noted that high-contrast vision of vertebrates is based on photon energy propagation along Muller cell (MC) IFs in the form of excitons, from the inner limiting membrane retinal layer to the outer fragments of cone cells, located in the outer limiting membrane retinal layer. Therefore, MC IFs operate as photon energy guides, transferring excitons from MC to cone cells, and thus communicating external visual information to the retinal cones and the brain. We finally conclude that apparently the mechanism based on the properties of IFs as natural energy guides plays the main role in communications within and between cells of live organisms. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.chemphys.2022.111595 | pt_PT |
| dc.identifier.issn | 0301-0104 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/18653 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.subject | Intermediate filaments | pt_PT |
| dc.subject | ATP | pt_PT |
| dc.subject | Exciton | pt_PT |
| dc.subject | Energy conductor | pt_PT |
| dc.subject | Exciton propagation | pt_PT |
| dc.title | Intermediate filaments are natural energy conductors in live cells | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.startPage | 111595 | pt_PT |
| oaire.citation.title | Chemical Physics | pt_PT |
| oaire.citation.volume | 561 | pt_PT |
| person.familyName | Khmelinskii | |
| person.givenName | Igor | |
| person.identifier | 0000000420541031 | |
| person.identifier.ciencia-id | 0D1A-CB6C-6316 | |
| person.identifier.orcid | 0000-0002-6116-184X | |
| person.identifier.rid | C-9587-2011 | |
| person.identifier.scopus-author-id | 6701444934 | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | fcb9f09f-2e99-41fb-8c08-7e1acbc65076 | |
| relation.isAuthorOfPublication.latestForDiscovery | fcb9f09f-2e99-41fb-8c08-7e1acbc65076 |