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Understanding the bioaccumulation of pharmaceutical active compounds by clams Ruditapes decussatus exposed to a UWWTP discharge

dc.contributor.authorCravo, Alexandra
dc.contributor.authorSilva, Sofia
dc.contributor.authorRodrigues, João
dc.contributor.authorCardoso, Vítor Vale
dc.contributor.authorBenoliel, Maria João
dc.contributor.authorCorreia, Cátia
dc.contributor.authorCoelho, Maria Rosário
dc.contributor.authorRosa, Maria João
dc.contributor.authorAlmeida, Cristina M.M.
dc.date.accessioned2022-07-13T10:13:28Z
dc.date.available2022-07-13T10:13:28Z
dc.date.issued2022
dc.description.abstractTwenty-four pharmaceutical active compounds (PhACs) were evaluated in the soft tissues of clams Ruditappes decussatus exposed along a 1.5-km dispersal gradient of the treated effluent from an urban wastewater treatment plant discharging in Ria Formosa, and compared with those in the marine waters and discharged effluents. The clams were exposed for 1 month, in June-July 2016, 2017 and 2018. PhACs were quantified by high performance liquid chromatography coupled to tandem mass spectrometry after the quick, easy, cheap, effective, rugged and safe (QuEChERS) method (clams) or solid-phase extraction (water samples). The most representative PhACs in the effluents and receiving waters (regardless of the tidal dilution effect) were diclofenac, carbamazepine and caffeine (on average <= 2 mu g/L) and only caffeine exhibited significant inter-annual differences, with higher values in 2017. In turn, the most bioaccumulated PhACs in clams were caffeine (0.54-27 ng/g wet weight, significantly higher in 2016) and acetaminophen (0.37-3.7 ng/g wet weight, significant lower in 2016). A multivariate principal component analysis showed (i) PhAC bioaccumulation primarily depended on biotic factors (clams length and weight), (ii) PhAC physicochemical properties Log Kow, pKa and water solubility interplaying with water abiotic variables were more relevant for explaining data variability in water than the physical dilution/tidal mixing, (iii) this process, reflected by the salinity gradient, had a tertiary role in data variation, responsible for spatial discrimination of marine waters. This study provides a better understanding of PhACs bioaccumulation by clams Ruditapes decussatus in real environmental conditions, under the influence of urban treated effluent dispersal in Ria Formosa coastal lagoon, a major producer of bivalves, ultimately disentangling key factors of PhAC bioaccumulation.pt_PT
dc.description.sponsorshipLIFE14 ENV/PT/000739
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.envres.2021.112632pt_PT
dc.identifier.issn0013-9351
dc.identifier.urihttp://hdl.handle.net/10400.1/17979
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectPharmaceutical active compoundspt_PT
dc.subjectRuditapes decussatuspt_PT
dc.subjectBioaccumulationpt_PT
dc.subjectMarine waterspt_PT
dc.subjectHPLC-MS/MSpt_PT
dc.titleUnderstanding the bioaccumulation of pharmaceutical active compounds by clams Ruditapes decussatus exposed to a UWWTP dischargept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage112632pt_PT
oaire.citation.titleEnvironmental Researchpt_PT
oaire.citation.volume208pt_PT
person.familyNameCravo
person.familyNameCorreia
person.givenNameAlexandra
person.givenNameCátia
person.identifier.ciencia-id7419-EE20-8039
person.identifier.ciencia-id3017-A30B-6C8E
person.identifier.orcid0000-0002-2569-3929
person.identifier.orcid0000-0002-2228-5292
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf19c20c8-9654-43db-841b-2c6f14979df5
relation.isAuthorOfPublicationba4f2a11-1f9c-49e9-af61-8c2306bbab5b
relation.isAuthorOfPublication.latestForDiscoveryba4f2a11-1f9c-49e9-af61-8c2306bbab5b

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