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Metabolic changes in response to food intake in somatostatin 1.1 deficient zebrafish

dc.contributor.authorChen, Jie
dc.contributor.authorYuan, Huiming
dc.contributor.authorGao, Jing
dc.contributor.authorLiu, Lu
dc.contributor.authorCanario, Adelino
dc.date.accessioned2024-11-19T09:12:07Z
dc.date.available2024-11-19T09:12:07Z
dc.date.issued2024-12
dc.description.abstractSomatostatin is a multifunctional hormone with several genes in teleost fishes. A zebrafish CRISPR/Cas9 knockout of the somatostatin 1.1 ( sst1.1 ) with persistent hyperglycaemia and hyperlipidaemia displayed reduced fecundity when fed brine shrimp ad libitum. Here, we investigated the effect of feeding brine shrimp one to three times a day on fecundity and liver transcriptomics of the sst1.1 mutant compared to their wild-type siblings to unravel molecular pathways associated with the phenotype. We find that the sst1.1 deficient zebrafish had high mortality when fed at the highest rate and that in both genotypes, growth and fecundity were proportional to food intake. Although glucose and cholesterol decreased substantially at the lowest level of feeding, they were still higher in the mutant than in the wild-type zebrafish. Furthermore, sst1.1 deficiency had a small but significant effect on the hepatic expression of protein, carbohydrate, and fatty acid biosynthesis genes, contributing to the mutant's diabetic phenotype.eng
dc.identifier.doi10.1016/j.genrep.2024.102062
dc.identifier.issn2452-0144
dc.identifier.urihttp://hdl.handle.net/10400.1/26289
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationSomatostatin regulation of fecundity and potential application to sturgeon roe production
dc.relation.ispartofGene Reports
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSomatostatin 1.1
dc.subjectFeeding level
dc.subjectGlucose
dc.subjectCholesterol
dc.subjectFecundity
dc.subjectLiver
dc.subjectTranscriptomics
dc.titleMetabolic changes in response to food intake in somatostatin 1.1 deficient zebrafisheng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleSomatostatin regulation of fecundity and potential application to sturgeon roe production
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.awardURIhttp://hdl.handle.net/10400.1/25960
oaire.citation.titleGene Reports
oaire.citation.volume37
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameChen
person.familyNameCanario
person.givenNameJie
person.givenNameAdelino
person.identifier143624
person.identifier.ciencia-id9210-A59A-9203
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id56568523700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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