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Role of ancillary techniques in the differential diagnosis of salivary gland carcinomas

2025-02Journal article Restricted access
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dc.contributor.authorPaiva Correia, Antonio
dc.contributor.authorHellquist, Henrik
dc.contributor.authorApolónio, Joana
dc.contributor.authorCastelo-Branco, Pedro
dc.date.accessioned2025-03-07T11:14:51Z
dc.date.available2025-03-07T11:14:51Z
dc.date.issued2025-02
dc.description.abstractPaiva-Correia A, Hellquist H, Apolónio J, Castelo-Branco P. Role of ancillary techniques in the differential diagnosis of salivary gland carcinomas. The diagnosis of salivary gland carcinomas (SGC) rests mainly on histology, but immunohistochemical and molecular investigations are often necessary for differential diagnosis. This review is primarily aimed as a tool for pathologists in non-specialised head and neck hospitals who encounter a limited number of SGC annually. The use of testing an initial antibody panel, which may comprise both positive and negative expression for a suspected entity, and examples of different panels are outlined. We also focused on acinic cell carcinoma (AcCC), which is positive for DOG1 and negative for mammaglobin, whilst secretory carcinoma (SC) is positive for mammaglobin and negative for DOG1. In addition, the exclusive expression of androgen and HER2 in salivary duct carcinoma (SDC) and its use for differential diagnosis are also addressed. This review also highlights the particularities of mucoepidermoid carcinoma (MEC) and its negativity for S100 and SOX10, which distinguishes it from some of its mimics. In laboratories with limited access to antibodies for SGC, we recommend inclusion of mammaglobin. The use of molecular techniques for the diagnosis of MEC (MAML2), SC (ETV6), adenoid cystic carcinoma (MYB), and AcCC (NR4A3) is discussed. We highlight the role of commonly available antibodies for the histological classification of SGC.eng
dc.identifier.doi10.1111/apm.70008
dc.identifier.eissn1600-0463
dc.identifier.issn0903-4641
dc.identifier.urihttp://hdl.handle.net/10400.1/26871
dc.language.isoeng
dc.peerreviewedyes
dc.publisherScandinavian Societies for Pathology
dc.relation.ispartofAPMIS
dc.rights.uriN/A
dc.subjectBiomarkers
dc.subjectImmunohistochemistry
dc.subjectMolecular events
dc.subjectSalivary glands carcinoma
dc.titleRole of ancillary techniques in the differential diagnosis of salivary gland carcinomaseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.startPagee70008
oaire.citation.titleJournal of Pathology, Microbiology and Immunology
oaire.citation.volume133
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamePaiva Correia
person.familyNameHellquist
person.familyNameApolónio
person.familyNameCastelo-Branco
person.givenNameAntonio
person.givenNameHenrik
person.givenNameJoana
person.givenNamePedro
person.identifier.ciencia-id9C11-221B-93BF
person.identifier.ciencia-id791E-9E39-2795
person.identifier.ciencia-idE015-7F8F-5CA1
person.identifier.orcid0000-0001-8725-0202
person.identifier.orcid0000-0003-3044-6065
person.identifier.orcid0000-0002-9727-1813
person.identifier.orcid0000-0002-3453-3978
relation.isAuthorOfPublicationf8203149-8981-4f75-9463-afb5badb2122
relation.isAuthorOfPublicatione632b82a-cf09-4f9a-b445-9d9a9de47438
relation.isAuthorOfPublication01cf2be1-ea9f-4082-bcc6-e50fe4ad9fe1
relation.isAuthorOfPublicationbb25b5ad-1769-42be-a7d3-8fe76215aa23
relation.isAuthorOfPublication.latestForDiscoverye632b82a-cf09-4f9a-b445-9d9a9de47438

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