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Proteomic changes in Corbicula fluminea exposed to wastewater from a psychiatric hospital

2016-07Journal article Restricted access
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dc.contributor.authorBebianno, Maria João
dc.contributor.authorSroda, S.
dc.contributor.authorGomes, Tânia
dc.contributor.authorChan, P.
dc.contributor.authorBonnafe, E.
dc.contributor.authorBUDZINSKI, Hélène
dc.contributor.authorGeret, F.
dc.date.accessioned2017-04-07T15:57:00Z
dc.date.available2017-04-07T15:57:00Z
dc.date.issued2016-07
dc.description.abstractThe increase use of pharmaceutical compounds in veterinary practice and human population results in the ubiquitous presence of these compounds in aquatic ecosystems. Because pharmaceuticals are highly bioactive, there is concern about their toxicological effects in aquatic organisms. Therefore, the aim of this study was to assess the effects of an effluent from a psychiatric hospital (containing a complex mixture of 25 pharmaceutical compounds from eleven therapeutic classes) on the freshwater clam Corbicula fluminea using a proteomic approach. The exposure of C. fluminea to this complex effluent containing anxiolytics, analgesics, lipid regulators, beta blockers, antidepressants, antiepileptics, antihistamines, antihypertensives, antiplatelets and antiarrhythmics induced protein changes after 1 day of exposure in clam gills and digestive gland more evident in the digestive gland. These changes included increase in the abundance of proteins associated with structural (actin and tubulin), cellular functions (calreticulin, proliferating cell nuclear antigen (PCNA), T complex protein 1 (TCP1)) and metabolism (aldehyde dehydrogenase (ALDH), alcohol dehydrogenase, 6 phosphogluconate dehydrogenase). Results from this study indicate that calreticulin, PCNA, ALDH and alcohol dehydrogenase in the digestive gland and T complex protein 1 (TCP1)) and 6 phosphogluconate dehydrogenase in the gills represent useful biomarkers for the ecotoxicological characterization of psychiatric hospital effluents in this species.
dc.identifier.doi10.1007/s11356-015-5395-5
dc.identifier.issn0944-1344
dc.identifier.otherAUT: MBE00379;
dc.identifier.urihttp://hdl.handle.net/10400.1/9586
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Verlag
dc.relation.isbasedonWOS:000373609300008
dc.titleProteomic changes in Corbicula fluminea exposed to wastewater from a psychiatric hospital
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage5055
oaire.citation.issue6
oaire.citation.startPage5046
oaire.citation.titleEnvironmental Science and Pollution Research
oaire.citation.volume23
person.familyNameBebianno
person.familyNameGomes
person.familyNameBUDZINSKI
person.givenNameMaria
person.givenNameTânia
person.givenNameHélène
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0003-1492-8566
person.identifier.orcid0000-0001-6179-4543
person.identifier.orcid0000-0003-1028-9154
person.identifier.scopus-author-id7004152715
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication71dcd70c-3a6a-45f7-bbe7-6b8a5346cc88
relation.isAuthorOfPublicationd2ad7c79-1ccb-423b-aae7-525ecab9724e
relation.isAuthorOfPublication.latestForDiscoveryd2ad7c79-1ccb-423b-aae7-525ecab9724e

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