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Antioxidant and lipid peroxidation responses in Mytilus galloprovincialis exposed to mixtures of benzo(a)pyrene and copper

2011Journal article Restricted access
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dc.contributor.authorMaria, Vera L.
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2020-04-28T09:45:09Z
dc.date.available2020-04-28T09:45:09Z
dc.date.issued2011
dc.description.abstractThis study aimed to assess the antioxidant system potential and lipid peroxidative effects, in the gill and digestive gland of Mytilus galloprovincialis exposed to individual and binary mixtures of benzo(a)pyrene (BaP) and Cu for 7 days. Data demonstrated that in mussels exposed to BaP antioxidant enzymes (catalase--CAT, total glutathione peroxidase--tGPx, glutathione S-transferase--GST and glutathione reductase--GR) and lipid peroxidation (LPO) increased in the gill. On the contrary, in the digestive gland inhibitory antioxidant effects (superoxide dismutase-SOD, GR, metallothioneins-MT) and no changes in LPO levels were detected. Cu was also a potent oxidant agent since MT and LPO levels increased in mussel gill, despite no LPO effect in the digestive gland. For both single contaminants the organ specificity and distinct physiologic/metabolism roles were evident in terms of antioxidant capacity. Gill SOD inhibition, MT and GST unchanged was a result of "simple independent action" of exposure to BaP and Cu. "Interactions" in the binary mixtures, led to absence of changes in LPO effects. In the digestive gland, BaP and Cu interactions were also responsible for the GST and LPO enhancement (antagonistic effects). The current findings demonstrate the differences in antioxidant responses where the organ dependency highlights each contaminant particular mode of action. Generally, in the gill "non-interactive" effects occurred with the lowest Cu concentration while "interactions" exist for the mixture with the highest Cu concentrations. In the digestive gland, "interactions" and "no interaction" effects occurred in all the binary mixtures. Complex contaminant mixtures interact differently based on target tissue which may lead to an imbalance in the mussels health status.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.cbpc.2011.02.004pt_PT
dc.identifier.issn0010-406X
dc.identifier.urihttp://hdl.handle.net/10400.1/13793
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1532045611000202?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnalysis of variancept_PT
dc.subjectAnimalspt_PT
dc.subjectAntioxidantspt_PT
dc.subjectBenzo(a)pyrenept_PT
dc.subjectCatalasept_PT
dc.subjectCopperpt_PT
dc.subjectDigestive systempt_PT
dc.subjectGillspt_PT
dc.subjectGlutathione peroxidasept_PT
dc.subjectGlutathione reductasept_PT
dc.subjectGlutathione transferasept_PT
dc.subjectLipid peroxidationpt_PT
dc.subjectMalondialdehydept_PT
dc.subjectMetallothioneinpt_PT
dc.subjectMytiluspt_PT
dc.subjectSuperoxide dismutasept_PT
dc.titleAntioxidant and lipid peroxidation responses in Mytilus galloprovincialis exposed to mixtures of benzo(a)pyrene and copperpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F26970%2F2006/PT
oaire.citation.endPage63pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage56pt_PT
oaire.citation.titleComparative Biochemistry and Physiology - Part C: Toxicology and Pharmacologypt_PT
oaire.citation.volume154pt_PT
oaire.fundingStreamSFRH
person.familyNameMaria
person.familyNameBebianno
person.givenNameVera Lúcia
person.givenNameMaria
person.identifier.ciencia-id7C1D-5627-D3BC
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0002-0331-3489
person.identifier.orcid0000-0003-1492-8566
person.identifier.ridI-5142-2013
person.identifier.scopus-author-id7004664869
person.identifier.scopus-author-id7004152715
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication18c7065a-4bd7-42b2-ba58-ae4c064554b9
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
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