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European Sea Bass (Dicentrarchus labrax) immune status and disease resistance are impaired by arginine dietary supplementation

2015-10Journal article Open access
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dc.contributor.authorAzeredo, Rita
dc.contributor.authorPerez-Sanchez, Jaume
dc.contributor.authorSitja-Bobadilla, Ariadna
dc.contributor.authorFouz, Belen
dc.contributor.authorTort, Lluis
dc.contributor.authorAragao, Claudia
dc.contributor.authorOliva-Teles, Aires
dc.contributor.authorCostas, Benjamin
dc.date.accessioned2018-12-07T14:58:09Z
dc.date.available2018-12-07T14:58:09Z
dc.date.issued2015-10
dc.description.abstractInfectious diseases and fish feeds management are probably the major expenses in the aquaculture business. Hence, it is a priority to define sustainable strategies which simultaneously avoid therapeutic procedures and reinforce fish immunity. Currently, one preferred approach is the use of immunostimulants which can be supplemented to the fish diets. Arginine is a versatile amino acid with important mechanisms closely related to the immune response. Aiming at finding out how arginine affects the innate immune status or improve disease resistance of European seabass (Dicentrarchus labrax) against vibriosis, fish were fed two arginine-supplemented diets (1% and 2% arginine supplementation). A third diet meeting arginine requirement level for seabass served as control diet. Following 15 or 29 days of feeding, fish were sampled for blood, spleen and gut to assess cell-mediated immune parameters and immune-related gene expression. At the same time, fish from each dietary group were challenged against Vibrio anguillarum and survival was monitored. Cell-mediated immune parameters such as the extracellular superoxide and nitric oxide decreased in fish fed arginine-supplemented diets. Interleukins and immune-cell marker transcripts were down-regulated by the highest supplementation level. Disease resistance data were in accordance with a generally depressed immune status, with increased susceptibility to vibriosis in fish fed arginine supplemented diets. Altogether, these results suggest a general inhibitory effect of arginine on the immune defences and disease resistance of European seabass. Still, further research will certainly clarify arginine immunomodulation pathways thereby allowing the validation of its potential as a prophylactic strategy.
dc.description.sponsorshipEuropean Union's Seventh Framework Programme AQUAEXCEL (Aquaculture Infrastructures for Excellence in European Fish Research) [262336]; AQUAIMPROV [NORTE-07-0124-FEDER-000038]; North Portugal Regional Operational Programme (ON. 2 - O Novo Norte) , under the National Strategic Reference Framework, through the European Regional Development Fund; North Portugal Regional Operational Programme (ON. 2 - O Novo Norte), under the National Strategic Reference Framework through the COMPETE - Operational Competitiveness Programme; Fundacao para a Ciencia e Tecnologia; Fundacao para a Ciencia e Tecnologia [SFRH/BD/89457/2012, SFRH/BPD/77210/2011]; Generalitat Valenciana through the project REVIDPAQUA [ISIC/2012/003]; [PEst-C/MAR/LA0015/2013]; [UID/Multi/04423/2013]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1371/journal.pone.0139967
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10400.1/11887
dc.language.isoeng
dc.peerreviewedyes
dc.publisherPublic Library of Science
dc.relationINTERACTIVE EFFECTS OF FISH MEAL REPLACEMENT BY PLANT PROTEIN SOURCES AND NOVEL IMMUNOSTIMULATING NUTRIENTS ON INNATE IMMUNE MECHANISMS AND DISEASE RESISTANCE IN FISH: TOWARDS FUNCTIONAL AND SUSTAINABLE FEEDS
dc.relationAMINO ACIDS AS NOVEL NUTRACEUTICS TO MODULATE IMMUNE MECHANISMS AND INCREASE DISEASE RESISTANCE IN FISH
dc.relationAQUAculture infrastructures for EXCELLence in European Fish research
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectInduced inflammatory response
dc.subjectCarpio Var. Jian
dc.subjectGrowth-performance
dc.subjectAeromonas-Salmonicida
dc.subjectVibrio-Anguillarum
dc.subjectJuvenile jian
dc.subjectAmino-acids
dc.subjectIn-vitro
dc.subjectFish
dc.subjectGlutamine
dc.titleEuropean Sea Bass (Dicentrarchus labrax) immune status and disease resistance are impaired by arginine dietary supplementation
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleINTERACTIVE EFFECTS OF FISH MEAL REPLACEMENT BY PLANT PROTEIN SOURCES AND NOVEL IMMUNOSTIMULATING NUTRIENTS ON INNATE IMMUNE MECHANISMS AND DISEASE RESISTANCE IN FISH: TOWARDS FUNCTIONAL AND SUSTAINABLE FEEDS
oaire.awardTitleAMINO ACIDS AS NOVEL NUTRACEUTICS TO MODULATE IMMUNE MECHANISMS AND INCREASE DISEASE RESISTANCE IN FISH
oaire.awardTitleAQUAculture infrastructures for EXCELLence in European Fish research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F77210%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F89457%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/262336/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04423%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FMAR%2FLA0015%2F2013/PT
oaire.citation.issue10
oaire.citation.startPagee0139967
oaire.citation.titlePLoS ONE
oaire.citation.volume10
oaire.fundingStreamFP7
oaire.fundingStream5876
oaire.fundingStreamCOMPETE
person.familyNameAragão
person.givenNameCláudia
person.identifier174173
person.identifier.ciencia-idD01E-0726-9F3E
person.identifier.orcid0000-0002-9217-0183
person.identifier.ridK-2310-2012
person.identifier.scopus-author-id55903315700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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