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Valorization of arbutus unedo L. Pomace: exploring the recovery of bioactive phenolic compounds from distillation By-products

2025-02-27Journal article Open access
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dc.contributor.authorLorenzo, Ritamaria Di
dc.contributor.authorFerraro, Maria Grazia
dc.contributor.authorCarrera, Ceferino
dc.contributor.authorIazzetti, Federica
dc.contributor.authorChinchilla, Nuria
dc.contributor.authorMaisto, Maria
dc.contributor.authorAliaño González, María José
dc.contributor.authorPiccolo, Vincenzo
dc.contributor.authorRicci, Lucia
dc.contributor.authorMedronho, Bruno
dc.contributor.authorMarzocchi, Adua
dc.contributor.authorPiccolo, Marialuisa
dc.contributor.authorRomano, Anabela
dc.contributor.authorTenore, Gian Carlo
dc.contributor.authorIrace, Carlo
dc.contributor.authorLaneri, Sonia
dc.date.accessioned2025-04-22T09:19:24Z
dc.date.available2025-04-22T09:19:24Z
dc.date.issued2025-02-27
dc.description.abstractThis study explores the potential of Arbutus unedo L. pomace, a by-product of the food industry, as a natural ingredient for skincare applications. In Portugal, A. unedo L. fruits are traditionally used to produce "Aguardente de Medronho", a spirit with a protected geographical indication. The distillation process generates pomace, comprising skins, pulp remnants, seeds, and residual alcohol rich in phenolic compounds, whose levels are significantly increased during distillation. In addition to their documented high antioxidant content, these residues also display notable antimicrobial properties. However, their potential benefits for skin health have not yet been explored. The methodology entailed the preparation of the pomace extract and a comprehensive analysis of its polyphenolic content and antioxidant capacity under laboratory conditions and in preclinical cellular models. The by-products demonstrated a high polyphenol content and potent antioxidant activity, comparable to vitamin C. Bioscreening on human skin models (i.e., dermal fibroblasts and keratinocytes) revealed their ability to reduce reactive oxygen species (ROS) formation under oxidative stress in skin cells, highlighting their potential to mitigate skin aging and damage caused by environmental pollutants. Moreover, bioscreens in vitro revealed a high safety profile, without any interference with cell viability at concentrations up to 100 mu g/mL. These findings support the use of A. unedo L. pomace extract as a sustainable ingredient for the development of antioxidant-rich and eco-friendly cosmetic or dermatologic products.eng
dc.description.sponsorshipUCA/R155REC/2021, 304747/2020-3, 309955/2022-0
dc.identifier.doi10.3390/antiox14030278
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/10400.1/27063
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relation.ispartofAntioxidants
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectArbutus unedo
dc.subjectPomace
dc.subjectBy-product
dc.subjectCosmetic
dc.subjectPolyphenols
dc.subjectAntioxidant
dc.subjectSkin cells
dc.titleValorization of arbutus unedo L. Pomace: exploring the recovery of bioactive phenolic compounds from distillation By-productseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.startPage278
oaire.citation.titleAntioxidants
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAliaño González
person.familyNameRomano
person.givenNameMaría José
person.givenNameAnabela
person.identifier456042
person.identifier.ciencia-idDD17-3640-DB88
person.identifier.ciencia-id8A18-7E9A-3B0E
person.identifier.orcid0000-0002-5816-4476
person.identifier.orcid0000-0002-7204-7428
person.identifier.scopus-author-id57200221253
person.identifier.scopus-author-id56249997600
relation.isAuthorOfPublication305fc84f-d79e-49d4-ba14-bea107dcc203
relation.isAuthorOfPublicatione3343b60-17d3-4f5e-a2bf-06f26da69206
relation.isAuthorOfPublication.latestForDiscovery305fc84f-d79e-49d4-ba14-bea107dcc203

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