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Comprehensive metabolomics and lipidomics profiling of prostate cancer tissue reveals metabolic dysregulations associated with disease development

2021-03Journal article Restricted access
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dc.contributor.authorLima, Ana Rita
dc.contributor.authorCarvalho, Márcia
dc.contributor.authorAveiro, Susana
dc.contributor.authorMelo, Tânia
dc.contributor.authorDomingues, M. Rosário
dc.contributor.authorMacedo-Silva, Catarina
dc.contributor.authorCoimbra, Nuno
dc.contributor.authorJerónimo, Carmen
dc.contributor.authorHenrique, Rui
dc.contributor.authorBastos, Maria de Lourdes
dc.contributor.authorGuedes de Pinho, Paula
dc.contributor.authorPinto, Joana
dc.date.accessioned2022-09-22T11:26:47Z
dc.date.available2022-09-22T11:26:47Z
dc.date.issued2021-03
dc.description.abstractProstate cancer (PCa) is a global health problem that affects millions of men every year. In the past decade, metabolomics and related subareas, such as lipidomics, have demonstrated an enormous potential to identify novel mechanisms underlying PCa development and progression, providing a good basis for the development of new and more effective therapies and diagnostics. In this study, a multiplatform metabolomics and lipidomics approach, combining untargeted mass spectrometry (MS) and nuclear magnetic resonance (NMR)-based techniques, was applied to PCa tissues to investigate dysregulations associated with PCa development, in a cohort of 40 patients submitted to radical prostatectomy for PCa. Results revealed significant alterations in the levels of 26 metabolites and 21 phospholipid species in PCa tissue compared with adjacent nonmalignant tissue, suggesting dysregulation in 13 metabolic pathways associated with PCa development. The most affected metabolic pathways were amino acid metabolism, nicotinate and nicotinamide metabolism, purine metabolism, and glycerophospholipid metabolism. A clear interconnection between metabolites and phospholipid species participating in these pathways was observed through correlation analysis. Overall, these dysregulations may reflect the reprogramming of metabolic responses to produce high levels of cellular building blocks required for rapid PCa cell proliferation.pt_PT
dc.description.sponsorshipPOCI-01-0145-FEDER-030388
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1021/acs.jproteome.1c00754pt_PT
dc.identifier.eissn1535-3907
dc.identifier.urihttp://hdl.handle.net/10400.1/18280
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.subjectProstate cancerpt_PT
dc.subjectTissuept_PT
dc.subjectMetabolomicspt_PT
dc.subjectLipidomicspt_PT
dc.subjectMetabolic pathwayspt_PT
dc.titleComprehensive metabolomics and lipidomics profiling of prostate cancer tissue reveals metabolic dysregulations associated with disease developmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FSAU-SER%2F30388%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.citation.endPage739pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage727pt_PT
oaire.citation.titleJournal of Proteome Researchpt_PT
oaire.citation.volume21pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAveiro
person.givenNameSusana
person.identifier.ciencia-idD312-07B4-DA74
person.identifier.orcid0000-0002-6651-3226
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoveryed8b83e5-9fb0-4701-a65e-90690ccc139c
relation.isProjectOfPublicationb5bf8b0e-bb76-4f52-8cd5-ad0472b8b3a9
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