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Antioxidant and cytotoxic activities of sulfated polysaccharides from five different edible seaweeds

2020Journal article Open access
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dc.contributor.authorArunkumar, K.
dc.contributor.authorRathinam, Raja
dc.contributor.authorKumar, V. B. Sameer
dc.contributor.authorJoseph, Ashna
dc.contributor.authorShilpa, T.
dc.contributor.authorCarvalho, Isabel S.
dc.date.accessioned2020-10-14T09:42:09Z
dc.date.available2020-10-14T09:42:09Z
dc.date.issued2020
dc.description.abstractIn recent times, there has been a growing interest in the exploration of antioxidants and global trend toward the usage of seaweeds in the food industries. The low molecular weight up to 14 kDa sulfated polysaccharides of seaweeds (Portieria hornemannii, Spyridia hypnoides, Asparagopsis taxiformis, Centroceras clavulatum and Padina pavonica) were evaluated for in vitro antioxidant activities and cytotoxic assay using HeLa cell line and also characterized by FTIR. The high yield (7.74% alga dry wt.) of sulfated polysaccharide was observed in P. hornemannii followed by S. hypnoides (0.69%), C. clavulaum (0.55%) and A. taxiformis (0.17%). In the brown seaweed P. pavonica, the sulfated polysaccharide yield was 2.07%. High amount of sulfate was recorded in the polysaccharide of A. taxiformis followed by C. clavulaum, P. pavonica, S. hypnoides and P. hornemannii as indicative for bioactivity. The FTIR spectroscopic analysis supports the sulfated polysaccharides of S. hypnoides, C. clavulatum and A. taxiformis are similar to agar polymer whereas the spectral characteristics of P. hornemannii have similarities to carrageenan. The higher DPPH activity and reducing power were recorded in the polysaccharide of brown seaweed P. pavonica than the red seaweeds as follows: DPPH activities: S. hypnoides > A. taxiformis > C. clavulatum > P. hornimanii; Reducing power: A. taxiformis > P. hornimanii > S. hypnoides > C. clavulatum. The polysaccharide fractions contain up to 14 kDa from red seaweeds P. hornemannii and S. hypnoides followed by brown seaweed P. pavonica exhibit cytotoxic activity in HeLa cancer cell line (and are similar to structural properties of carrageenan extracted from P. hornemannii). The low molecular weight agar like polymer of S. hypnoides and alginate like brown seaweed P. pavonica showing better in vitro antioxidant activities that are capable of exhibiting cytotoxicity against HeLa cell line can be taken up further in-depth investigation for nutraceutical study.pt_PT
dc.description.sponsorshipUniversity of Algarve: DL 57/2016pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1007/s11694-020-00661-4pt_PT
dc.identifier.issn2193-4126
dc.identifier.urihttp://hdl.handle.net/10400.1/14771
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSeaweedspt_PT
dc.subjectHeLa cell linespt_PT
dc.subjectSulfated polysaccharidespt_PT
dc.subjectAntioxidantspt_PT
dc.subjectCytotoxic assaypt_PT
dc.titleAntioxidant and cytotoxic activities of sulfated polysaccharides from five different edible seaweedspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Food Measurement and Characterizationpt_PT
person.familyNameRathinam
person.familyNameSaraiva de Carvalho
person.givenNameRaja
person.givenNameIsabel Maria Marques
person.identifier.ciencia-id591A-3777-B036
person.identifier.orcid0000-0002-8445-6034
person.identifier.orcid0000-0001-8057-3404
person.identifier.ridM-8564-2013
person.identifier.scopus-author-id16029399900
person.identifier.scopus-author-id35995183800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcf31fff2-143a-4f1f-ab45-7074ade0179b
relation.isAuthorOfPublicationaf26e659-578b-4e5f-a649-384cd5e4f8e3
relation.isAuthorOfPublication.latestForDiscoverycf31fff2-143a-4f1f-ab45-7074ade0179b

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