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Mediterranean asteraceae as natural sources of antioxidants and enzyme inhibitors: a case study on urospermum dalechampii and andryala integrifolia from Tunisia

2026-06Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg15:Proteger a Vida Terrestre
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorHammami, Nourhen
dc.contributor.authorRodrigues, Maria João
dc.contributor.authorFernandes, Eliana
dc.contributor.authorStegemann, Thomas
dc.contributor.authorSaadellaoui, Wissal
dc.contributor.authorHannachi, Hédia
dc.date.accessioned2026-07-02T09:18:47Z
dc.date.available2026-07-02T09:18:47Z
dc.date.issued2026-06
dc.description.abstractThis study investigated the phenolic composition, antioxidant capacity, and key enzyme-inhibitory activities of hydroethanolic leaf extracts from two Mediterranean Asteraceae, Urospermum dalechampii and Andryala integrifolia, from Tunisia. U. dalechampii exhibited higher total phenolic content (62.84 mg GAE/g crude extract), whereas A. integrifolia showed higher flavonoids (34.55 mg QE/g crude extract). The UHPLC-DAD-MS analysis revealed caffeoylquinic acid isomers, flavonols (quercetin and kaempferol types), and flavones (luteolin derivatives) in both species, while cynarine was detected in U. dalechampii. Some compounds were specific, such as caftaric acid, which was detected only in U. dalechampii leaf extract. Both species exhibited notable antioxidant capacities, with U. dalechampii showing stronger radical-scavenging activity (DPPH: EC50 = 0.95 mg/mL; ABTS: EC50 = 0.72 mg/mL), whereas A. integrifolia displayed higher reducing power (FRAP: EC50 = 5.40 mg/mL) and copper-chelating activity (EC50 = 1.72 mg/mL). A. integrifolia showed marked inhibition of tyrosinase (IC50 = 0.54 mg/mL), α-glucosidase (IC50 = 1.9 mg/mL), and lipase (IC50 = 9.7 mg/mL). Both leaf extracts from studied species inhibited AChE, while only A. integrifolia inhibited BChE (IC50 = 8.63 mg/mL). No cytotoxicity was detected at 100 μg/mL in human hepatocarcinoma (HepG2), neuroblastoma (SH-SY5Y), embryonic kidney (HEK-293), and murine melanoma (B16) cells. These results highlight these two plants as a promising source of multifunctional bioactive compounds and demonstrate that unexploited wild plants could offer new prospects for pharmaceutical and nutraceutical applications.eng
dc.description.sponsorshipUID/04326/2025; UID/PRR/04326/2025
dc.identifier.doi10.1002/cbdv.71434
dc.identifier.eissn1612-1880
dc.identifier.issn1612-1872
dc.identifier.urihttp://hdl.handle.net/10400.1/29194
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relationCentre for Marine and Environmental Research
dc.relationAlgarve Centre for Marine Sciences
dc.relation.ispartofChemistry & Biodiversity
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCaffeoylquinic acid
dc.subjectQuercetin
dc.subjectTyrosinase
dc.subjectCholinesterase
dc.subjectα-glucosidase
dc.subjectMetal chelation
dc.subjectCytotoxicity
dc.titleMediterranean asteraceae as natural sources of antioxidants and enzyme inhibitors: a case study on urospermum dalechampii and andryala integrifolia from Tunisiaeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberLA/P/0101/2020
oaire.awardNumberUIDP/04326/2020
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04326%2F2020/PT
oaire.citation.issue6
oaire.citation.titleChemistry & Biodiversity
oaire.citation.volume23
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRodrigues
person.familyNameFernandes
person.givenNameMaria João
person.givenNameEliana
person.identifierR-004-VNG
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0003-4083-8353
person.identifier.scopus-author-id56031608100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isAuthorOfPublication43a963c0-f7ed-4fbb-8fc5-753251ac5a7d
relation.isAuthorOfPublication.latestForDiscovery12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isProjectOfPublication794d4c77-c731-471e-bc96-5a41dcd3d872
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relation.isProjectOfPublication.latestForDiscovery794d4c77-c731-471e-bc96-5a41dcd3d872

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