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The transcriptional landscape of the photosynthetic model cyanobacterium synechocystis sp PCC6803

2016-02Journal article Open access
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dc.contributor.authorHernandez-Prieto, Miguel A.
dc.contributor.authorSemeniuk, Trudi Ann
dc.contributor.authorJoaquín, Giner-Lamia
dc.contributor.authorFutschik, Matthias E.
dc.date.accessioned2017-04-07T15:57:07Z
dc.date.available2017-04-07T15:57:07Z
dc.date.issued2016-02
dc.description.abstractCyanobacteria exhibit a great capacity to adapt to different environmental conditions through changes in gene expression. Although this plasticity has been extensively studied in the model cyanobacterium Synechocystis sp. PCC 6803, a detailed analysis of the coordinated transcriptional adaption across varying conditions is lacking. Here, we report a meta-analysis of 756 individual microarray measurements conducted in 37 independent studies-the most comprehensive study of the Synechocystis transcriptome to date. Using stringent statistical evaluation, we characterized the coordinated adaptation of Synechocystis' gene expression on systems level. Evaluation of the data revealed that the photosynthetic apparatus is subjected to greater changes in expression than other cellular components. Nevertheless, network analyses indicated a significant degree of transcriptional coordination of photosynthesis and various metabolic processes, and revealed the tight co-regulation of components of photosystems I, II and phycobilisomes. Detailed inspection of the integrated data led to the discovery a variety of regulatory patterns and novel putative photosynthetic genes. Intriguingly, global clustering analyses suggested contrasting transcriptional response of metabolic and regulatory genes stress to conditions. The integrated Synechocystis transcriptome can be accessed and interactively analyzed via the CyanoEXpress website (http://cyanoexpress.sysbiolab.eu).
dc.identifier.doi10.1038/srep22168
dc.identifier.issn2045-2322
dc.identifier.otherAUT: MFU02241;
dc.identifier.urihttp://hdl.handle.net/10400.1/9616
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNature Research
dc.relationDeciphering the gene regulatory networks of cyanobacteria
dc.relationThe regulation of photosynthesis in cyanobacteria: A systems biology approach
dc.relation.isbasedonWOS:000371108100001
dc.titleThe transcriptional landscape of the photosynthetic model cyanobacterium synechocystis sp PCC6803
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDeciphering the gene regulatory networks of cyanobacteria
oaire.awardTitleThe regulation of photosynthesis in cyanobacteria: A systems biology approach
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIC%2F101036%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00881%2F2013%2FCP1198%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIC%2F4418%2F2012/PT
oaire.citation.endPage22168
oaire.citation.startPage22168
oaire.citation.titleScientific Reports
oaire.citation.volume6
oaire.fundingStream3599-PPCDT
oaire.fundingStreamInvestigador FCT
oaire.fundingStream3599-PPCDT
person.familyNameHernández-Prieto
person.familyNameGiner
person.familyNameFutschik
person.givenNameMiguel Angel
person.givenNameJoaquin
person.givenNameMatthias
person.identifier336659
person.identifier.ciencia-idA71B-AD01-3501
person.identifier.orcid0000-0001-7950-1526
person.identifier.orcid0000-0003-1553-8295
person.identifier.orcid0000-0002-6245-8071
person.identifier.scopus-author-id26430696600
person.identifier.scopus-author-id55329443800
person.identifier.scopus-author-id14017989400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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