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Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms

2016-02Journal article Open access
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dc.contributor.authorRathore, Om
dc.contributor.authorFaustino, Alexandra
dc.contributor.authorPrudencio, Pedro
dc.contributor.authorVan Damme, Petra
dc.contributor.authorCox, C. J.
dc.contributor.authorMartinho, Rui Goncalo
dc.date.accessioned2017-04-07T15:57:09Z
dc.date.available2017-04-07T15:57:09Z
dc.date.issued2016-02
dc.description.abstractProtein N-terminal acetylation is an ancient and ubiquitous co-translational modification catalyzed by a highly conserved family of N-terminal acetyltransferases (NATs). Prokaryotes have at least 3 NATs, whereas humans have six distinct but highly conserved NATs, suggesting an increase in regulatory complexity of this modification during eukaryotic evolution. Despite this, and against our initial expectations, we determined that NAT diversification did not occur in the eukaryotes, as all six major human NATs were most likely present in the Last Eukaryotic Common Ancestor (LECA). Furthermore, we also observed that some NATs were actually secondarily lost during evolution of major eukaryotic lineages; therefore, the increased complexity of the higher eukaryotic proteome occurred without a concomitant diversification of NAT complexes.
dc.identifier.doi10.1038/srep21304
dc.identifier.issn2045-2322
dc.identifier.otherAUT: RGM02492;
dc.identifier.urihttp://hdl.handle.net/10400.1/9625
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNature Publishing Group
dc.relationPD/00117/2012
dc.relationProtein targeting and N-terminal acetylation
dc.relationREGULATION OF PRE-MRNA SPLICING DURING DROSOPHILA DEVELOPMENT
dc.relation.isbasedonWOS:000369830800001
dc.titleAbsence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleProtein targeting and N-terminal acetylation
oaire.awardTitleREGULATION OF PRE-MRNA SPLICING DURING DROSOPHILA DEVELOPMENT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBBB-BQB%2F0712%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F52428%2F2013/PT
oaire.citation.endPage21304
oaire.citation.startPage21304
oaire.citation.titleScientific Reports
oaire.citation.volume6
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStreamOE
person.familyNameRathore
person.familyNamePrudêncio
person.familyNameCox
person.familyNameViegas Russo da Conceição Martinho
person.givenNameOm
person.givenNamePedro
person.givenNameCymon
person.givenNameRui Gonçalo
person.identifier.ciencia-id7B1C-9F36-22C8
person.identifier.ciencia-id6B15-9771-1D04
person.identifier.ciencia-idF31D-C783-3D89
person.identifier.orcid0000-0003-3858-557X
person.identifier.orcid0000-0003-1390-8491
person.identifier.orcid0000-0002-4927-979X
person.identifier.orcid0000-0002-1641-3403
person.identifier.ridM-7546-2013
person.identifier.ridD-1303-2012
person.identifier.scopus-author-id54884299400
person.identifier.scopus-author-id7402112716
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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