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Changes in metabolism of inorganic polyphosphate in rat tissues and human cells during development and apoptosis
| dc.contributor.author | Lorenz, B. | |
| dc.contributor.author | Munkner, J. | |
| dc.contributor.author | Oliveira, M. P. | |
| dc.contributor.author | Kuusksalu, A. | |
| dc.contributor.author | Leitão, J. M. | |
| dc.contributor.author | Muller, W. E. G. | |
| dc.contributor.author | Schroder, H. C. | |
| dc.date.accessioned | 2015-06-19T14:36:29Z | |
| dc.date.available | 2015-06-19T14:36:29Z | |
| dc.date.issued | 1997 | |
| dc.description.abstract | Age-dependent studies show that the amount of inorganic polyphosphate in rat brain strongly increases after birth. Maximal levels were found in 12-months old animals. Thereafter, the concentration of total polyphosphate decreases to about 50%. This decrease in the concentration of total polyphosphate is due to a decrease in the amount of insoluble, long-chain polyphosphates. The amount of soluble, long-chain polyphosphates does not change significantly in the course of ageing. In rat embryos and newborns, mainly soluble polyphosphates could be detected. In rat liver, the age-dependent changes are less pronounced. The changes in polyphosphate level are accompanied by changes in exopolyphosphatase activity, which degrades the polymers to orthophosphate; highest enzyme activities were found when the polyphosphate level was low, Induction of apoptosis in the human leukemic cell line HL-60 by actinomycin D results in degradation of long polyphosphate chains. The total polyphosphate content does not change significantly in apoptotic cells. | |
| dc.identifier.doi | https://dx.doi.org/10.1016/S0304-4165(96)00121-3 | |
| dc.identifier.issn | 0304-4165 | |
| dc.identifier.other | AUT: JLE00446; | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/6525 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Elsevier | |
| dc.relation.isbasedon | P-001-BKP | |
| dc.title | Changes in metabolism of inorganic polyphosphate in rat tissues and human cells during development and apoptosis | |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 60 | |
| oaire.citation.startPage | 51 | |
| oaire.citation.title | Biochimica et Biophysica Acta - General Subjects | |
| oaire.citation.volume | 1335 | |
| person.familyName | Leitão | |
| person.givenName | José | |
| person.identifier | 258398 | |
| person.identifier.ciencia-id | 7A17-3E0A-73AD | |
| person.identifier.orcid | 0000-0003-4278-0415 | |
| person.identifier.rid | AAH-3958-2020 | |
| person.identifier.scopus-author-id | 7005119796 | |
| rcaap.rights | restrictedAccess | |
| rcaap.type | article | |
| relation.isAuthorOfPublication | 0f990d1c-2913-4f8a-8fb6-f8b02721247f | |
| relation.isAuthorOfPublication.latestForDiscovery | 0f990d1c-2913-4f8a-8fb6-f8b02721247f |
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