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Prepubertal gonad investment modulates thymus function: evidence in a teleost fish

2021-01Journal article Restricted access
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dc.contributor.authorPaiola, Matthieu
dc.contributor.authorMoreira, Catarina
dc.contributor.authorHétru, Julie
dc.contributor.authorDuflot, Aurélie
dc.contributor.authorPinto, Patrícia
dc.contributor.authorScapigliati, Giuseppe
dc.contributor.authorKnigge, Thomas
dc.contributor.authorMonsinjon, Tiphaine
dc.date.accessioned2021-04-12T14:18:09Z
dc.date.available2022-03-01T01:30:14Z
dc.date.issued2021-01
dc.description.abstractThymus plasticity following gonadectomy or sex hormone replacement has long since exemplified sex hormone effects on the immune system in mammals and, to a lesser extent, in 'lower vertebrates', including amphibians and fish. Nevertheless, the underlying physiological significances as well as the ontogenetic establishment of this crosstalk remain largely unknown. Here, we used a teleost fish, the European sea bass, Dicentrarchus labrax, to investigate: (1) whether the regulation of thymus plasticity relies on resource trade-off with somatic growth and reproductive investment and (2) if the gonad-thymus interaction takes place during gonadal differentiation and development. Because gonadal development and, supposedly, thymus function in sea bass depend on environmental changes associated with the winter season, we evaluated thymus changes (foxn1 expression, and thymocyte and T cell content) in juvenile D. labrax raised for 1 year under either constant or fluctuating photoperiod and temperature. Importantly, in both conditions, intensive gonadal development following sex differentiation coincided with a halt of thymus growth, while somatic growth continued. To the best of our knowledge, this is the first study showing that gonadal development during prepuberty regulates thymus plasticity. This finding may provide an explanation for the initiation of the thymus involution related to ageing in mammals. Comparing fixed and variable environmental conditions, our work also demonstrates that the extent of the effects on the thymus, which are related to reproduction, depend on ecophysiological conditions, rather than being directly related to sexual maturity and sex hormone levels.pt_PT
dc.description.sponsorshipFCT: UIDB/04326/2020/ DL57/2016/CP1361/CT0015pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1242/jeb.238576pt_PT
dc.identifier.issn0022-0949
dc.identifier.urihttp://hdl.handle.net/10400.1/15366
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe Company of Biologistspt_PT
dc.subject11-Ketotestosteronept_PT
dc.subjectThymic epithelial cellpt_PT
dc.subject17β-Oestradiolpt_PT
dc.subjectT-lymphocytept_PT
dc.subjectGonadal developmentpt_PT
dc.subjectLife history theorypt_PT
dc.titlePrepubertal gonad investment modulates thymus function: evidence in a teleost fishpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.startPagejeb238576pt_PT
oaire.citation.titleThe Journal of Experimental Biologypt_PT
oaire.citation.volume224pt_PT
person.familyNamePinto
person.givenNamePatrícia
person.identifier.ciencia-id1215-D615-204C
person.identifier.orcid0000-0002-3153-2830
person.identifier.ridC-3197-2018
person.identifier.scopus-author-id57200566502
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9edd3100-4c78-4492-bd19-469a31b7253a
relation.isAuthorOfPublication.latestForDiscovery9edd3100-4c78-4492-bd19-469a31b7253a

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