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Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: a comparative study

2020-10Journal article Restricted
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dc.contributor.authorZengin, Gokhan
dc.contributor.authorSinan, Kouadio Ibrahime
dc.contributor.authorAk, Gunes
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorPaksoy, Mehmet Yavuz
dc.contributor.authorPicot-Allain, Carene
dc.contributor.authorGlamocilja, Jasmina
dc.contributor.authorSokovic, Marina
dc.contributor.authorJeko, Jozsef
dc.contributor.authorCziaky, Zoltan
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorPereira, Catarina
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2021-06-24T11:35:13Z
dc.date.available2021-06-24T11:35:13Z
dc.date.issued2020-10
dc.description.abstractSeveral Apiaceae species, used as both food and in complementary and alternative medicine, represents a rich source of potential valuable phytopharmaceuticals which necessitates scientific contemplation. In the present study, the antioxidant, enzyme inhibitory, antimicrobial, and cytotoxic properties of methanol extracts of seven Apiaceae species, (Chaerophyllum macrospermum (Willd. ex Spreng.) Fisch. & C.A.Mey. ex Hohen, Ferula rigidula Fisch. ex DC., Ferula orientalis L., Prangos ferulacea Lindl., Prangos peucedanifolia Fenzl., Ferulago setifolia K. Koch, and Pimpinella anthriscoides Boiss.) were evaluated. Species belonging to the Prangos genus exhibited the highest total phenolic content, namely P. peucedanifolia and P. ferulacea, with values of 47.90 and 44.44 mg gallic acid equivalent/g extract, respectively. P. peucedanifolia also displayed the highest radical scavenging capacity (81.53 and 102.70 mg Trolox equivalent [TE]/g extract for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS), respectively) and reducing power (165.87 and 100.09 mg TE/g extract for cupric reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP), respectively). C. macrospermum showed the most potent inhibition against Alzheimer's disease related enzymes, namely acetylcholinesterase (4.53 mg galantamine equivalent [GALAE]/g extract) and butyrylcholinesterase (3.22 mg GALAE/g extract). P. ferulacea (131.94 mg kojic acid (KAE) equivalent/g extract) and P. peucedanifolia (4.97 mmol acarbose equivalent (ACAE)/g extract) were potent inhibitors of tyrosinase and a-glucosidase, respectively. In general, studied species were able to reduce cellular viabilities. P. peucedanifolia possessed promising antibacterial potential against Bacillus cereus (Minimum inhibition concentration (MIC): 0.37 mg/mL), L. monocytogenes (MIC: 0.56 mg/mL), P. aeruginosa and Escherichia coli (MIC: 0.27 mg/mL), Salmonella typhimurium and Enterobacter cloacae (MIC: 0.75 mg/mL). F. rigidula showed the highest antifungal effect against Aspergillus ochraceus and Trichoderma viride (MIC: 0.10 mg/mL). The present findings could be the scientific starting point towards the pharmaceutical and/or commercial utilization of these Apiaceae species.
dc.description.sponsorshipMinistry of Education, Science and Technological Development, Republic of Serbia [451-03-68/2020-14/200007]
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.indcrop.2020.112572
dc.identifier.issn0926-6690
dc.identifier.urihttp://hdl.handle.net/10400.1/16377
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.subjectApiaceae
dc.subjectAntioxidant
dc.subjectAntimicrobial
dc.subjectCytotoxic
dc.subjectBioactive compounds
dc.subject.otherAgriculture
dc.titleChemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: a comparative study
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage112572
oaire.citation.titleIndustrial Crops and Products
oaire.citation.volume153
person.familyNameRodrigues
person.familyNameGuerreiro Pereira
person.familyNameCustódio
person.givenNameMaria João
person.givenNameCatarina Alexandra
person.givenNameLuísa
person.identifierR-004-VNG
person.identifierNmxO5SIAAAAJ
person.identifier.ciencia-id2514-0E17-1D8D
person.identifier.ciencia-id4512-3435-689C
person.identifier.ciencia-id791B-C560-AEA2
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0002-1131-8773
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id15831018900
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication12c32925-de9e-4289-bdd5-1d655d7a278c
relation.isAuthorOfPublication164572fc-85ed-4377-afd0-7ab4c8fdc79f
relation.isAuthorOfPublicationf9cfed0f-6b67-413e-988c-ac7397183471
relation.isAuthorOfPublication.latestForDiscovery164572fc-85ed-4377-afd0-7ab4c8fdc79f

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