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Salt pan brine water sulphated polysaccharides retrieved at pilot scale: ability to stimulate in vitro human macrophages and salmon head kidney cells

2025-06Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg14:Proteger a Vida Marinha
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorFerreira, Sónia S.
dc.contributor.authorPereira, Renato B.
dc.contributor.authorBordalo, Diana
dc.contributor.authorBarbosa, Helena
dc.contributor.authorFerreira, Nicole
dc.contributor.authorCorreia, Alexandra
dc.contributor.authorFerreira, Paula
dc.contributor.authorRodrigues, Alexandre M. C.
dc.contributor.authorNavalho, João
dc.contributor.authorPereira, Eduarda
dc.contributor.authorVilanova, Manuel
dc.contributor.authorNunes, Cláudia
dc.contributor.authorCoimbra, Manuel A.
dc.contributor.authorPinto, Bruno
dc.date.accessioned2026-04-15T10:14:00Z
dc.date.available2026-04-15T10:14:00Z
dc.date.issued2025-06
dc.description.abstractMarine environments are the warehouse of a variety of novel bioactive compounds prone to be explored by food and feed industry. The growing interest in sulphated polysaccharides has led to the search for new sustainable sources, such as seawater. These compounds are naturally concentrated in salt pan brine water due to their evaporation by wind and sunlight. To take advantage of these sources, sulphated polysaccharides were concentrated from salt pan brine water using a scalable membrane ultrafiltration system with 30 and 100 kDa cut-off. This process allowed to concentrate ten times the polymeric material of brine water into 1.9 g/L, rendering a fluffy polysaccharide rich material after drying. It was mainly composed of 23 % (w/w) of uronic acids, 19 % of sulphate esters, and 34 % (w/w) of neutral sugars. This polymeric material has shown to stimulate in vitro both human macrophages and Atlantic salmon head kidney SHK-1 cells in a range of 6.25–50 μg/mL without toxicity, showing potential to be used in both human food and aquaculture feeding.eng
dc.description.sponsorshipLA/P/0008/2020
dc.identifier.doi10.1016/j.ijbiomac.2025.144506
dc.identifier.issn0141-8130
dc.identifier.urihttp://hdl.handle.net/10400.1/28679
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationCICECO-Aveiro Institute of Materials
dc.relationCICECO – Aveiro Institute of Materials
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectMarine polymers
dc.subjectDiafiltration
dc.subjectHuman macrophages THP-1
dc.titleSalt pan brine water sulphated polysaccharides retrieved at pilot scale: ability to stimulate in vitro human macrophages and salmon head kidney cellseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDP/50006/2020
oaire.awardNumberUIDB/50006/2020
oaire.awardNumberUIDB/50011/2020
oaire.awardNumberLA/P/0006/2020
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleCICECO-Aveiro Institute of Materials
oaire.awardTitleCICECO – Aveiro Institute of Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0006%2F2020/PT
oaire.citation.startPage144506
oaire.citation.titleInternational Journal of Biological Macromolecules
oaire.citation.volume317
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamePinto
person.givenNameBruno
person.identifier.orcid0000-0002-6507-7207
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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