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Gla-Rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in Didabetic patients with moderate CKD

2022-02-15Journal article Open access
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dc.contributor.authorSilva, Ana P.
dc.contributor.authorViegas, Carla
dc.contributor.authorGuilherme, Patrícia
dc.contributor.authorTavares, Nelson
dc.contributor.authorDias, Carolina
dc.contributor.authorRato, Fátima
dc.contributor.authorSantos, Nélio
dc.contributor.authorFaísca, Marília
dc.contributor.authorde Almeida, Edgar
dc.contributor.authorNeves, Pedro L.
dc.contributor.authorSimes, Dina C.
dc.date.accessioned2022-03-02T16:20:38Z
dc.date.available2022-03-02T16:20:38Z
dc.date.issued2022-02-15
dc.date.updated2022-02-24T14:50:06Z
dc.description.abstractAccelerated and premature cardiovascular calcification is a hallmark of chronic kidney disease (CKD) patients. Valvular calcification (VC) is a critical indicator of cardiovascular disease and all-cause mortality in this population, lacking validated biomarkers for early diagnosis. Gla-rich protein (GRP) is a cardiovascular calcification inhibitor recently associated with vascular calcification, pulse pressure, mineral metabolism markers and kidney function. Here, we examined the association between GRP serum levels and mitral and aortic valves calcification in a cohort of 80 diabetic patients with CKD stages 2–4. Mitral and aortic valves calcification were detected in 36.2% and 34.4% of the patients and associated with lower GRP levels, even after adjustments for age and gender. In this pilot study, univariate, multivariate and Poisson regression analysis, show that low levels of GRP and magnesium (Mg), and high levels of phosphate (P) are associated with mitral and aortic valves calcification. Receiver operating characteristic (ROC) curves showed that the area under the curve (AUC) values of GRP for mitral (0.762) and aortic (0.802) valves calcification were higher than those of Mg and P. These results suggest that low levels of GRP and Mg, and high levels of P, are independent and cumulative risk factors for VC in this population; the GRP diagnostic value might be potentially useful in cardiovascular risk assessment.pt_PT
dc.description.sponsorship41/ALG/2020—Project nº 072583—NUTRISAFE
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifierdoi: 10.3390/diagnostics12020496
dc.identifier.citationDiagnostics 12 (2): 496 (2022)pt_PT
dc.identifier.doi10.3390/diagnostics12020496pt_PT
dc.identifier.issn2075-4418
dc.identifier.urihttp://hdl.handle.net/10400.1/17623
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationNot Available
dc.relationAlgarve Centre for Marine Sciences
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectChronic kidney diseasept_PT
dc.subjectCardiovascular calcificationpt_PT
dc.subjectValvular calcificationpt_PT
dc.subjectVascular calcificationpt_PT
dc.subjectCardiovascular diseasept_PT
dc.subjectGla-rich proteinpt_PT
dc.subjectCardiovascular risk assessmentpt_PT
dc.titleGla-Rich protein, magnesium and phosphate associate with mitral and aortic valves calcification in Didabetic patients with moderate CKDpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNot Available
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/DL 57%2F2016/DL 57%2F2016%2FCP1361%2FCT0006/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FBTM-TEC%2F0990%2F2021/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT
oaire.citation.issue2pt_PT
oaire.citation.startPage496pt_PT
oaire.citation.titleDiagnosticspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStreamDL 57/2016
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameViegas
person.familyNameDias
person.familyNameNeves
person.familyNameSimes
person.givenNameCarla
person.givenNameAna Carolina
person.givenNamePedro Leão
person.givenNameDina
person.identifier.ciencia-idC414-F596-EEC6
person.identifier.ciencia-id2F10-4DE3-123F
person.identifier.ciencia-id1014-3EA2-C680
person.identifier.orcid0000-0002-5765-3665
person.identifier.orcid0000-0002-8463-0768
person.identifier.orcid0000-0002-5145-4753
person.identifier.ridN-6695-2014
person.identifier.ridN-2789-2014
person.identifier.scopus-author-id8656310300
person.identifier.scopus-author-id7003907170
person.identifier.scopus-author-id7201884723
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication33984b3c-ffac-477a-896a-ddbf7aced4e3
relation.isAuthorOfPublication8360e087-7ef8-47e0-954c-b819f96dcb19
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relation.isAuthorOfPublication.latestForDiscovery8360e087-7ef8-47e0-954c-b819f96dcb19
relation.isProjectOfPublicationd8b35409-7782-4fa8-b62e-a0b938094f94
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