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Sulfated seaweed polysaccharides as multifunctional materials in drug delivery applications

2016-07Journal article Open Access
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dc.contributor.authorCunha, Ludmylla
dc.contributor.authorGrenha, Ana
dc.date.accessioned2017-04-07T15:56:59Z
dc.date.available2017-04-07T15:56:59Z
dc.date.issued2016-07
dc.description.abstractIn the last decades, the discovery of metabolites from marine resources showing biological activity has increased significantly. Among marine resources, seaweed is a valuable source of structurally diverse bioactive compounds. The cell walls of marine algae are rich in sulfated polysaccharides, including carrageenan in red algae, ulvan in green algae and fucoidan in brown algae. Sulfated polysaccharides have been increasingly studied over the years in the pharmaceutical field, given their potential usefulness in applications such as the design of drug delivery systems. The purpose of this review is to discuss potential applications of these polymers in drug delivery systems, with a focus on carrageenan, ulvan and fucoidan. General information regarding structure, extraction process and physicochemical properties is presented, along with a brief reference to reported biological activities. For each material, specific applications under the scope of drug delivery are described, addressing in privileged manner particulate carriers, as well as hydrogels and beads. A final section approaches the application of sulfated polysaccharides in targeted drug delivery, focusing with particular interest the capacity for macrophage targeting.
dc.identifier.doi10.3390/md14030042
dc.identifier.issn1660-3397
dc.identifier.otherAUT: AMG02212;
dc.identifier.urihttp://hdl.handle.net/10400.1/9582
dc.language.isoeng
dc.peerreviewedyes
dc.relationFighting TB: Development of microparticulate systems to target alveolar macrophages in tuberculosis therapy
dc.relation.isbasedonWOS:000373701200002
dc.titleSulfated seaweed polysaccharides as multifunctional materials in drug delivery applications
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleFighting TB: Development of microparticulate systems to target alveolar macrophages in tuberculosis therapy
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-FTO%2F0094%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIM%2F04773%2F2013/PT
oaire.citation.issue3
oaire.citation.titleMarine drugs
oaire.citation.volume14
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameCunha
person.familyNameGrenha
person.givenNameLudmylla Costa
person.givenNameAna
person.identifier.ciencia-id091C-0D58-7225
person.identifier.orcid0000-0003-2620-5760
person.identifier.orcid0000-0002-2136-1396
person.identifier.ridH-1392-2017
person.identifier.scopus-author-id8607930100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
rcaap.typearticle
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