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Kinetic model of cadmium accumulation and elimination and metallothionein response in Ruditapes decussatus

2007-05Journal article Restricted access
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dc.contributor.authorSerafim, Angela
dc.contributor.authorBebianno, Maria João
dc.date.accessioned2020-05-06T14:08:40Z
dc.date.available2020-05-06T14:08:40Z
dc.date.issued2007-05
dc.description.abstractThe aim of the present study was to determine the response of metallothionein (MT) during Cd accumulation and elimination in different tissues of the estuarine bivalve Ruditapes decussatus exposed to two nominal Cd concentrations (4 and 40 microg/L) for 40 d, followed by a depuration period of 50 d. Cadmium was accumulated in all tissues of R. decussatus at both exposure concentrations, and the accumulation was tissue dependent. Use of the kinetic model showed that in the gills and remaining tissues, Cd was assimilated faster at the beginning of the exposure and decreased with time, possibly limited by the diffusion rate of this metal within the cell. In the digestive gland, however, the Cd was continuously accumulated. This could reflect that the Cd uptake rate is considerably higher than the loss rate and, therefore, that this tissue has a higher capacity to accumulate Cd compared to the other two tissues. Moreover, the application of this kinetic model in the different subcellular fractions showed that the bioconcentration factor was significantly higher in the low-molecular-weight fraction (where MT is found), suggesting that this fraction binds Cd faster, with a high uptake rate (K(u) = 32/d), and eliminates this metal more slowly (K(1) = 0.005/d). During the depuration phase, MT decreased simultaneously with Cd elimination in all tissues, although with a shorter half-life. In conclusion, the MT response prevented Cd in the tissues of R. decussatus from interfering in the normal clam metabolism; therefore, MT acts as a detoxification mechanism of Cd.pt_PT
dc.description.sponsorshipThis study was supported by the Fundacão para a Ciência e a Tecnologia (FCT) grant (CIÊNCIA/BD/2541/93).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1897/06-237r.1pt_PT
dc.identifier.issn0730-7268
dc.identifier.urihttp://hdl.handle.net/10400.1/13844
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSociety of Environmental Toxicology and Chemistry Presspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectBivalviapt_PT
dc.subjectCadmiumpt_PT
dc.subjectDose-response relationshippt_PT
dc.subjectKineticspt_PT
dc.subjectMetallothioneinpt_PT
dc.subjectModelspt_PT
dc.subjectMolecular weightpt_PT
dc.subjectTime factorspt_PT
dc.subjectTissue distributionpt_PT
dc.subjectWater pollutantspt_PT
dc.subjectEnvironmental monitoringpt_PT
dc.subjectDrugpt_PT
dc.subjectBiologicalpt_PT
dc.subjectChemicalpt_PT
dc.subjectBioaccumulationpt_PT
dc.subjectRuditapes decussatuspt_PT
dc.titleKinetic model of cadmium accumulation and elimination and metallothionein response in Ruditapes decussatuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage969pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage960pt_PT
oaire.citation.titleEnvironmental Toxicology and Chemistrypt_PT
oaire.citation.volume26pt_PT
person.familyNamePereira Serafim
person.familyNameBebianno
person.givenNameMaria Angela
person.givenNameMaria
person.identifier.ciencia-id9C18-090A-5E3D
person.identifier.ciencia-id2B11-46AC-B94B
person.identifier.orcid0000-0002-1165-0645
person.identifier.orcid0000-0003-1492-8566
person.identifier.scopus-author-id7004152715
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0e42fc03-7052-438d-952b-b3caa5bdc36a
relation.isAuthorOfPublication2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32
relation.isAuthorOfPublication.latestForDiscovery2e00a26d-1dd3-4c22-a6bf-ac7943ae0d32

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