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Propolis influence on erythrocyte membrane disorder (hereditary spherocytosis): a first approach

2011Journal article Restricted access
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dc.contributor.authorMoreira, Leandro L.
dc.contributor.authorDias, Teresa
dc.contributor.authorDias, Luís G.
dc.contributor.authorRogão, Mónica
dc.contributor.authorSilva, José P. da
dc.contributor.authorEstevinho, Letícia M.
dc.date.accessioned2015-06-22T14:13:51Z
dc.date.available2015-06-22T14:13:51Z
dc.date.issued2011
dc.description.abstractPropolis is a resinous substance collected from plants by bees. Its composition depends on the vegetation, the season, and the source area. It usually contains many chemical compounds such as polyphenols, steroids and amino acids. The hereditary spherocytosis (HS) is a type of anaemia characterized by microcytic and hyperchromic red cells, spherical in shape and without central pallor. Clinically, subjects present from asymptomatic conditions to severe haemolytic anaemia. In this study it was evaluated the effect of two propolis extracts in the osmotic fragility of HS patient red blood cell (RBC) membrane. It was found that propolis decreases the erythrocytes membrane fragility, being the effect of Bornes propolis more pronounced than Fundao propolis'. This effect was related with the higher phenolic content of the former propolis. The results obtained in vitro suggest that the membrane fragility increases under oxidative stress conditions for the patient RBC's and the protection effect of propolis is due to its antioxidant properties. These results open doors for future investigations in order to elucidate the mechanisms, identify the main compounds involved in this fragility protection of the erythrocyte membrane. This is the first work reporting an evaluation of the propolis effect in a blood disease. (C) 2010 Elsevier Ltd. All rights reserved.
dc.identifier.doihttps://dx.doi.org/10.1016/j.fct.2010.11.042
dc.identifier.issn0278-6915
dc.identifier.urihttp://hdl.handle.net/10400.1/6566
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.isbasedonP-002-VKK
dc.subjectBee product
dc.subjectPhenolic compounds
dc.subjectErythrocyte membrane
dc.subjectApis mellifera
dc.titlePropolis influence on erythrocyte membrane disorder (hereditary spherocytosis): a first approach
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage526
oaire.citation.issue2
oaire.citation.startPage520
oaire.citation.titleFood and Chemical Toxicology
oaire.citation.volume49
person.familyNameDa Silva
person.givenNameJosé Paulo
person.identifier.ciencia-id3413-C4F4-73F7
person.identifier.orcid0000-0002-6458-7328
person.identifier.ridA-4606-2008
person.identifier.scopus-author-id7201733236
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublicatione2004fa2-a47d-44b0-b11c-fc95fe51cbf9
relation.isAuthorOfPublication.latestForDiscoverye2004fa2-a47d-44b0-b11c-fc95fe51cbf9

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