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Red algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae

2018-05Journal article Open access
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dc.contributor.authorCarson, Matthew A.
dc.contributor.authorNelson, John
dc.contributor.authorCancela, M. Leonor
dc.contributor.authorLaizé, Vincent
dc.contributor.authorGavaia, Paulo J.
dc.contributor.authorRae, Margaret
dc.contributor.authorHeesch, Svenja
dc.contributor.authorVerzin, Eugene
dc.contributor.authorMaggs, Christine
dc.contributor.authorGilmore, Brendan F.
dc.contributor.authorClarke, Susan A.
dc.date.accessioned2018-12-07T14:57:51Z
dc.date.available2018-12-07T14:57:51Z
dc.date.issued2018-05
dc.description.abstractThrough the current trend for bioprospecting, marine organisms-particularly algae-are becoming increasingly known for their osteogenic potential. Such organisms may provide novel treatment options for osteoporosis and other musculoskeletal conditions, helping to address their large healthcare burden and the limitations of current therapies. In this study, extracts from two red algae-Plocamium lyngbyanum and Ceramium secundatum-were tested in vitro and in vivo for their osteogenic potential. In vitro, the growth of human bone marrow stromal cells (hBMSCs) was significantly greater in the presence of the extracts, particularly with P. lyngbyanum treatment. Osteogenic differentiation was promoted more by C. secundatum (70 mu g/ml), though P. lyngbyanum had greater in vitro mineralisation potential. Both species caused a marked and dose-dependent increase in the opercular bone area of zebrafish larvae. Our findings therefore indicate the presence of bioactive components in P. lyngbyanum and C. secundatum extracts, which can promote both in vitro and in vivo osteogenic activity.
dc.description.sponsorshipIrish Sea Change Strategy; Strategy for Science Technology and Innovation [20062013]; Marine Institute under the Marine Research Sub-Programme of the Irish National Development Plan; Santander (Bank, UK)
dc.identifier.doi10.1038/s41598-018-26024-0
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.1/11735
dc.language.isoeng
dc.peerreviewedyes
dc.publisherNature Publishing Group
dc.subjectPostmenopausal Osteoporosis
dc.subjectFracture Risk
dc.subjectDifferentiation
dc.subjectCells
dc.subjectVivo
dc.subjectWomen
dc.subjectMacroalgae
dc.subjectFucoidan
dc.subjectMen
dc.titleRed algal extracts from Plocamium lyngbyanum and Ceramium secundatum stimulate osteogenic activities in vitro and bone growth in zebrafish larvae
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage7725
oaire.citation.titleScientific Reports
oaire.citation.volume8
person.familyNameCancela
person.familyNameLaizé
person.familyNameGavaia
person.givenNameM. Leonor
person.givenNameVincent
person.givenNamePaulo
person.identifier.ciencia-idB619-FC16-D007
person.identifier.orcid0000-0003-3114-6662
person.identifier.orcid0000-0001-9565-9198
person.identifier.orcid0000-0002-9582-1957
person.identifier.ridB-4463-2008
person.identifier.ridA-6470-2011
person.identifier.scopus-author-id6602982778
person.identifier.scopus-author-id6507104377
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublicationb9bbfe32-3dfe-4131-ad14-a4394008447f
relation.isAuthorOfPublicationb51cd3d5-7ee4-47d8-9bc4-b3e297aa222f
relation.isAuthorOfPublication9dca2139-21a4-4d59-aaf7-531f1033a58e
relation.isAuthorOfPublication.latestForDiscoveryb51cd3d5-7ee4-47d8-9bc4-b3e297aa222f

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