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Oestrogen receptor distribution related to functional thymus anatomy of the European sea bass, Dicentrarchus labrax

2017-12Journal article Open access
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dc.contributor.authorPaiola, Matthieu
dc.contributor.authorKnigge, Thomas
dc.contributor.authorPicchietti, Simona
dc.contributor.authorDuflot, Aurelie
dc.contributor.authorGuerra, Laura
dc.contributor.authorPinto, Patricia IS
dc.contributor.authorScapigliati, Giuseppe
dc.contributor.authorMonsinjon, Tiphaine
dc.date.accessioned2019-11-20T15:07:11Z
dc.date.available2019-11-20T15:07:11Z
dc.date.issued2017-12
dc.description.abstractIn jawed vertebrates, the crosstalk between immune and endocrine system as well as many fundamental mechanisms of T cell development are evolutionary conserved. Oestrogens affect mammalian thymic function and plasticity, but the mechanisms of action and the oestrogen receptors involved remain unclear. To corroborate the oestrogenic regulation of thymic function in teleosts and to identify the implicated oestrogen receptor subtypes, we examined the distribution of nuclear and membrane oestrogen receptors within the thymus of the European Sea bass, Dicentrarchus labrax, in relation to its morpho-functional organisation. Immunohistological analysis specified thymus histology and organisation in teleosts and described, for the first time, Hassall's corpuscle like structures in the medulla of sea bass. All oestrogen receptors were expressed at the transcript and protein level, both in T cells and in stromal cells belonging to specific functional areas. These observations suggest complex regulatory actions of oestrogen on thymic function, notably through the stromal microenvironment, comprising both, genomic and non-genomic pathways that are likely to affect T cell maturation and trafficking processes. Comparison with birds, rodents and humans supports the thymic localization of oestrogen receptors and suggests that oestrogens modulate T cell maturation in all gnathostomes. (C) 2017 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipANR [ANR-15-CE32-0014]
dc.description.sponsorshipFR CNRS 3730 SCALE
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doi10.1016/j.dci.2017.07.023
dc.identifier.issn0145-305X
dc.identifier.issn1879-0089
dc.identifier.urihttp://hdl.handle.net/10400.1/12919
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationEnhancing Human Resources and Use of Appropriate Training for Maternal and Perinatal Survival In Sub-Saharan Africa
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectTrout salmo-gairdneri
dc.subjectT-cell
dc.subjectImmune-system
dc.subjectEpithelial-cells
dc.subjectGene-expression
dc.subjectTeleost fish
dc.subjectMast-Cell
dc.subjectInflammatory response
dc.subjectMyasthenia-gravis
dc.subjectLymphoid organs
dc.titleOestrogen receptor distribution related to functional thymus anatomy of the European sea bass, Dicentrarchus labrax
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEnhancing Human Resources and Use of Appropriate Training for Maternal and Perinatal Survival In Sub-Saharan Africa
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/266290/EU
oaire.citation.endPage120
oaire.citation.startPage106
oaire.citation.titleDevelopmental and Comparative Immunology
oaire.citation.volume77
oaire.fundingStreamFP7
person.familyNamePinto
person.givenNamePatricia IS
person.identifier643457
person.identifier.ciencia-idE51D-5CCB-B1C6
person.identifier.orcid0000-0001-7854-3898
person.identifier.ridM-3817-2013
person.identifier.scopus-author-id10240774300
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccess
rcaap.typearticle
relation.isAuthorOfPublication64bc526e-5281-44e5-91eb-5743436109f9
relation.isAuthorOfPublication.latestForDiscovery64bc526e-5281-44e5-91eb-5743436109f9
relation.isProjectOfPublicationd24d7acb-abc7-47aa-8a0b-9881285e60f3
relation.isProjectOfPublication.latestForDiscoveryd24d7acb-abc7-47aa-8a0b-9881285e60f3

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