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Molecular, cellular and histological changes in skin from a larval to an adult phenotype during bony fish metamorphosis

2007-02Journal article Restricted
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dc.contributor.authorCampinho, Marco António
dc.contributor.authorSilva, Nadia
dc.contributor.authorSweeney, Glen E.
dc.contributor.authorPower, Deborah
dc.date.accessioned2014-10-23T14:28:54Z
dc.date.available2014-10-23T14:28:54Z
dc.date.issued2007-02
dc.description.abstractDevelopmental models for skin exist in terrestrial and amphibious vertebrates but there is a lack of information in aquatic vertebrates. We have analysed skin epidermal development of a bony fish (teleost), the most successful group of extant vertebrates. A specific epidermal type I keratin cDNA (hhKer1), which may be a bony-fishspecific adaptation associated with the divergence of skin development (scale formation) compared with other vertebrates, has been cloned and characterized. The expression of hhKer1 and collagen 1α1 in skin taken together with the presence or absence of keratin bundle-like structures have made it possible to distinguish between larval and adult epidermal cells during skin development. The use of a flatfish with a well-defined larval to juvenile transition as a model of skin development has revealed that epidermal larval basal cells differentiate directly to epidermal adult basal cells at the climax of metamorphosis. Moreover,hhKer1 expression is downregulated at the climax of metamorphosis and is inversely correlated with increasing thyroxin levels. We suggest that, whereas early mechanisms of skin development between aquatic and terrestrial vertebrates are conserved, later mechanisms diverge.por
dc.description.sponsorshipWe thank Heiddis Smáradóttir of Fiskeldi Eyjafjarðar, IS-600 Akureyri, Iceland, for collecting and providing the halibut samples.por
dc.identifier.citationMarco A. Campinho & Nádia Silva & Glen E. Sweeney & Deborah M. Power, "Molecular, cellular and histological changes in skin from a larval to an adult phenotype during bony fish metamorphosis" in Cell Tissue Res (2007) 327:267–284.por
dc.identifier.doihttp://dx.doi.org/10.1007/s00441-006-0262-9
dc.identifier.issn0302-766X
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5431
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpringerpor
dc.relation.publisherversionhttp://link.springer.com/article/10.1007/s00441-006-0262-9por
dc.subjectEpidermal type I keratinpor
dc.subjectMetamorphosispor
dc.subjectThyroid hormonespor
dc.subjectSkin basal epidermal cellspor
dc.subjectHalibut, Hippoglossus hippoglossus (Teleostei)por
dc.titleMolecular, cellular and histological changes in skin from a larval to an adult phenotype during bony fish metamorphosispor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage284por
oaire.citation.issue2por
oaire.citation.startPage267por
oaire.citation.titleCell and Tissue Researchpor
oaire.citation.volume327por
person.familyNameCampinho
person.familyNameSilva
person.familyNamePower
person.givenNameMarco António
person.givenNameNádia
person.givenNameDeborah Mary
person.identifier.ciencia-id0E18-2560-6EC1
person.identifier.ciencia-id5D1F-6F3A-A1C2
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0002-5238-0506
person.identifier.orcid0000-0001-9881-4421
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridD-8833-2013
person.identifier.scopus-author-id8938999600
person.identifier.scopus-author-id10244362100
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationf8e8c466-6a6f-4ccf-b96d-34565fe53b6c
relation.isAuthorOfPublicationa467188c-1363-4f77-a9a9-8297de10a01a
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

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