Publicação
First insights on chemical nature and bioactivity of surface mucus from the Antarctic sponges Mycale (Oxymycale) acerata and Dendrilla antarctica
| datacite.subject.sdg | 14:Proteger a Vida Marinha | |
| datacite.subject.sdg | 09:Indústria, Inovação e Infraestruturas | |
| datacite.subject.sdg | 13:Ação Climática | |
| dc.contributor.author | Rizzo, Carmen | |
| dc.contributor.author | Silva, José Paulo da | |
| dc.contributor.author | Lauritano, Chiara | |
| dc.contributor.author | Montuori, Eleonora | |
| dc.contributor.author | Papale, Maria | |
| dc.contributor.author | Giudice, Angelina Lo | |
| dc.date.accessioned | 2026-03-03T12:56:13Z | |
| dc.date.available | 2026-03-03T12:56:13Z | |
| dc.date.issued | 2026-01-22 | |
| dc.description.abstract | The mucus produced by the Antarctic sponge species Mycale (Oxymycale) acerata and Dendrilla antarctica was ana¬lyzed to investigate its chemical composition and assess potential cytotoxic activity against human tumor cell lines. The mucus samples exhibited a high-water content (98–99%), while inorganic salts represented most of the total dry weight (67.1 ± 2.3%). Sodium was the most abundant element, accounting for 75% in D. antarctica and up to 82% in M. acerata. Other major elements—including magnesium, potassium, and calcium—comprised 3–10% of the inorganic fraction. Pro¬tein content was estimated at 0.44% for M. acerata and 5.63% for D. antarctica, with a carbon-to-nitrogen (C/N) ratio between 3 and 5. Elemental analysis was supported by μFT-IR spectroscopy, which confirmed the presence of inorganic salts, water, and proteinaceous materials. Further characterization by 1H NMR spectroscopy and LC–MS revealed the pres¬ence of amino acids, peptides, sugars, carboxylic acids, nitrogenous bases, and their derivatives. Notably, oxylipin concen¬trations ranged between 1 and 3 ng/L. In addition, M. acerata mucus demonstrated antiproliferative activity, selectively inhibiting the growth of Malme-3 M melanoma cell lines, thus suggesting a potential for cytotoxic effects. Overall, these findings provide the first chemical characterization of Antarctic sponge mucus, providing first insights for its potential exploitation as a novel source of bioactive compounds. | eng |
| dc.description.sponsorship | EMBRC.PT ALG-01-0145-FEDER-022121 | |
| dc.identifier.doi | 10.1007/s11696-025-04615-2 | |
| dc.identifier.eissn | 2585-7290 | |
| dc.identifier.issn | 0366-6352 | |
| dc.identifier.uri | http://hdl.handle.net/10400.1/28311 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | Springer | |
| dc.relation | Algarve Centre for Marine Sciences | |
| dc.relation | Algarve Centre for Marine Sciences | |
| dc.relation | Centre for Marine and Environmental Research | |
| dc.relation.ispartof | Chemical Papers | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | Antarctic | |
| dc.subject | Mycale acerata | |
| dc.subject | Dendrilla antarctica | |
| dc.subject | Mucus | |
| dc.subject | Chemical analysis | |
| dc.subject | Bioactivity | |
| dc.subject | Melanoma | |
| dc.title | First insights on chemical nature and bioactivity of surface mucus from the Antarctic sponges Mycale (Oxymycale) acerata and Dendrilla antarctica | eng |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardNumber | UIDB/04326/2020 | |
| oaire.awardNumber | UIDP/04326/2020 | |
| oaire.awardNumber | LA/P/0101/2020 | |
| oaire.awardTitle | Algarve Centre for Marine Sciences | |
| oaire.awardTitle | Algarve Centre for Marine Sciences | |
| oaire.awardTitle | Centre for Marine and Environmental Research | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04326%2F2020/PT | |
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| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT | |
| oaire.citation.title | Chemical Papers | |
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| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
| person.familyName | Silva | |
| person.givenName | José Paulo da | |
| person.identifier.ciencia-id | 3413-C4F4-73F7 | |
| person.identifier.orcid | 0000-0002-6458-7328 | |
| person.identifier.rid | A-4606-2008 | |
| person.identifier.scopus-author-id | 7201733236 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
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