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Inclusion complexes of rosmarinic acid and cyclodextrins: stoichiometry, association constants, and antioxidant potential

2014Journal article Restricted access
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dc.contributor.authorMedronho, B.
dc.contributor.authorValente, A. J. M.
dc.contributor.authorCosta, P.
dc.contributor.authorRomano, Anabela
dc.date.accessioned2015-06-18T10:12:36Z
dc.date.available2015-06-18T10:12:36Z
dc.date.issued2014
dc.description.abstractThe interaction between beta-cyclodextrin (beta-CD) and the polyphenol rosmarinic acid (RA) is here reported by H-1 NMR titration experiments. The formation of an aqueous soluble inclusion complex is confirmed and valuable information regarding mode of penetration of guest into beta-CD, stoichiometry, and stability of the complex is obtained. The analysis by the continuous variation method shows the undoubted formation of 1:1 beta-CD/RA complex. Additionally, the estimated apparent association constants reveal the importance of the asymmetry of the RA in the complexation; the incorporation of the catechol moiety closer to the carboxylic group is more favorable (K = 2,028 M-1) than from the other end of the RA molecule (K = 1,184 M-1). Finally, we have also investigated the antioxidant activity and storage stability of the beta-CD/RA complexed system; the presence of beta-CD was found to produce a remarkable enhancement on the antioxidant activity.
dc.identifier.doihttps://dx.doi.org/10.1007/s00396-013-3124-5
dc.identifier.issn0303-402X
dc.identifier.otherAUT: ARO01015;
dc.identifier.urihttp://hdl.handle.net/10400.1/6414
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.relation.isbasedonP-009-9QB
dc.relation.publisherversionhttp://link.springer.com/article/10.1007%2Fs00396-013-3124-5
dc.titleInclusion complexes of rosmarinic acid and cyclodextrins: stoichiometry, association constants, and antioxidant potential
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage894
oaire.citation.startPage885
oaire.citation.titleColloid and Polymer Science
oaire.citation.volume292
person.familyNameMedronho
person.familyNameRomano
person.givenNameBruno
person.givenNameAnabela
person.identifier.ciencia-id6918-9AB3-8D22
person.identifier.ciencia-id8A18-7E9A-3B0E
person.identifier.orcid0000-0003-0972-1739
person.identifier.orcid0000-0002-7204-7428
person.identifier.ridP-5927-2014
person.identifier.scopus-author-id9940656700
person.identifier.scopus-author-id56249997600
rcaap.rightsrestrictedAccess
rcaap.typearticle
relation.isAuthorOfPublication4c03571a-93da-4504-8acf-c74326449852
relation.isAuthorOfPublicatione3343b60-17d3-4f5e-a2bf-06f26da69206
relation.isAuthorOfPublication.latestForDiscoverye3343b60-17d3-4f5e-a2bf-06f26da69206

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