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Natural products from marine invertebrates against Leishmania parasites: a comprehensive review

2016-08Journal article Restricted access
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dc.contributor.authorOliveira, Marta
dc.contributor.authorBarreira, Luísa
dc.contributor.authorGangadhar, Katkam N.
dc.contributor.authorRodrigues, Maria Joao
dc.contributor.authorSantos, Tamara
dc.contributor.authorVarela, J.
dc.contributor.authorCustódio, Luísa
dc.date.accessioned2017-04-07T15:56:20Z
dc.date.available2017-04-07T15:56:20Z
dc.date.issued2016-08
dc.description.abstractParasitic infections by Leishmania parasites remains a severe public health problem, especially in developing countries where it is highly endemic. Chemotherapy still remains a first option for the treatment of those diseases, despite the fact that available drugs exhibit a variety of shortcomings. Thus, innovative, less toxic more affordable and effective antileishmanial agents are urgently needed. The marine environment holds an immeasurable bio- and chemical diversity, being a valuable source of natural products with therapeutic potential. As invertebrates comprise about 60 % of all marine organisms, bioprospecting this class of organisms for antileishmanial properties may unravel unique and selective hit molecules. In this context, this review covers results on the literature of marine invertebrate extracts and pure compounds evaluated against Leishmania parasites mainly by in vitro methods. It comprises results obtained from the phyla Porifera, Cnidaria, Bryozoa (Ectoprota), Mollusca, Echinodermata, Annelida, Cetnophora, Platyhelminthes, sub phyla Crustacea (phylum Arthropoda) and Tunicata (phylum Chordata). Moreover, structure-activity relationships and possible mechanisms of action are mentioned, whenever available information is provided. About 70 species of marine invertebrates belonging to seven different phyla are included in this work. Besides a variety of crude extracts, a total of 140 pure compounds was tested against different Leishmania species. Although the research on the antileishmanial potential of marine invertebrates is in its early beginnings, promising results have been achieved that encourage further research. As more extracts and compounds are being screened, the possibility of finding active and selective antileishmanial molecules increases, rising new hope in the search for new treatments against leishmaniases.
dc.identifier.doi10.1007/s11101-016-9455-3
dc.identifier.issn1568-7767
dc.identifier.otherAUT: LBA00541; JVA01305;
dc.identifier.urihttp://hdl.handle.net/10400.1/9383
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Verlag
dc.relationHalophytes: a precious resource of nutritional elements and bioactive compounds
dc.relationCentre of Marine Sciences
dc.relationBiologically Active Natural Products from Marine Organisms and Salt Marsh Plants (acronym: PharmaBlue)
dc.relationTECHNOLOGICAL IMPROVEMENTS OF BIODIESEL PRODUCTION USING OILS SYNTHESIZED BY MICROALGAE
dc.relation.isbasedonWOS:000379618900008
dc.subjectAntileishmanial activity
dc.subjectMarine invertebrates
dc.subjectParasitic infections
dc.subjectStructure–activity relationship (SAR)
dc.titleNatural products from marine invertebrates against Leishmania parasites: a comprehensive review
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHalophytes: a precious resource of nutritional elements and bioactive compounds
oaire.awardTitleCentre of Marine Sciences
oaire.awardTitleBiologically Active Natural Products from Marine Organisms and Salt Marsh Plants (acronym: PharmaBlue)
oaire.awardTitleTECHNOLOGICAL IMPROVEMENTS OF BIODIESEL PRODUCTION USING OILS SYNTHESIZED BY MICROALGAE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMAR-EST%2F4346%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04326%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00049%2F2012%2FCP0179%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F81882%2F2011/PT
oaire.citation.conferencePlacePlovdiv, BULGARIA
oaire.citation.endPage697
oaire.citation.issue4
oaire.citation.startPage663
oaire.citation.titlePhytochemistry Reviews
oaire.citation.volume15
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamInvestigador FCT
person.familyNameOliveira
person.familyNameBarreira
person.familyNameRodrigues
person.familyNameSantos
person.familyNameVarela
person.familyNameCustódio
person.givenNameMarta
person.givenNameLuísa
person.givenNameMaria João
person.givenNameTamara
person.givenNameJoão
person.givenNameLuísa
person.identifierR-004-VNG
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person.identifier.orcid0000-0002-4077-855X
person.identifier.orcid0000-0001-8732-710X
person.identifier.orcid0000-0001-9008-4436
person.identifier.orcid0000-0003-3101-693X
person.identifier.orcid0000-0003-4338-7703
person.identifier.ridM-4223-2013
person.identifier.ridM-6101-2013
person.identifier.scopus-author-id56031608100
person.identifier.scopus-author-id55741416000
person.identifier.scopus-author-id15831018900
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccess
rcaap.typearticle
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