Repository logo
 
Publication

Parathyroid hormone-related protein regulates intestinal calcium transport in sea bream (Sparus auratus)

2006-11-01Journal article Restricted access
Simple item page
dc.contributor.authorFuentes, J.
dc.contributor.authorFigueiredo, J.
dc.contributor.authorPower, Deborah
dc.contributor.authorCanario, Adelino V. M.
dc.date.accessioned2014-05-12T09:32:08Z
dc.date.available2014-05-12T09:32:08Z
dc.date.issued2006-11-01
dc.date.updated2014-05-09T08:38:12Z
dc.descriptionTexto integral disponível através do editor.
dc.description.abstractParathyroid hormone-related protein (PTHrP) is a factor associated with normal development and physiology of the nervous, cardiovascular, immune, reproductive, and musculoskeletal systems in higher vertebrates. It also stimulates whole body calcium uptake in sea bream (Sparus auratus) larvae with an estimated 60% coming from intestinal uptake in seawater. The present study investigated the role of PTHrP in the intestinal calcium transport in the sea bream in vitro. Unidirectional mucosal-to-serosal and serosal-to-mucosal 45Ca fluxes were measured in vitro in duodenum, hindgut, and rectum mounted in Ussing chambers. In symmetric conditions with the same saline, bathing apical and basolateral sides of the preparation addition of piscine PTHrP 1–34 (6 nM) to the serosal surface resulted in an increase in mucosal to serosal calcium fluxes in duodenum and hindgut and a reduction in serosal to mucosal in the rectum, indicating that different mechanisms are responsive to PTHrP along the intestine. In control asymmetric conditions, with serosal normal and mucosal bathed with a saline similar in composition to the intestinal fluid, there was a net increase in calcium uptake in all regions. The addition of 6 nM PTHrP 1–34 increased net calcium uptake two- to threefold in all regions. The stimulatory effect of PTHrP on net intestinal calcium absorption is consistent with a hypercalcemic role for the hormone. The results support the view that PTHrP, alone or in conjunction with recently identified PTH-like peptides, counteracts in vivo the hypocalcemic effects of stanniocalcin.por
dc.identifier.citationFuentes, J.; Figueiredo, J.; Power, D. M.; Canario, A. V. M.Parathyroid hormone-related protein regulates intestinal calcium transport in sea bream (Sparus auratus), American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 291, 5, R1499-R1506, 2006.por
dc.identifier.doihttp://dx.doi.org/10.1152/ajpregu.00892.2005
dc.identifier.issn0363-6119
dc.identifier.otherAUT: ACA00258; DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/3853
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherAmerican Physiological Societypor
dc.relation.publisherversionhttp://ajpregu.physiology.org/content/291/5/R1499.full-text.pdf+htmlpor
dc.subjectParathyroid hormonepor
dc.subjectProteinpor
dc.subjectSparus auratuspor
dc.titleParathyroid hormone-related protein regulates intestinal calcium transport in sea bream (Sparus auratus)por
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1506por
oaire.citation.startPage1499por
oaire.citation.titleAJP - Regulatory, Integrative and Comparative Physiologypor
oaire.citation.volume291por
person.familyNameFuentes
person.familyNamePower
person.familyNameCanario
person.givenNameJuan
person.givenNameDeborah Mary
person.givenNameAdelino
person.identifier392998
person.identifier143624
person.identifier.ciencia-id421B-E196-2C33
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0003-0430-8734
person.identifier.orcid0000-0003-1366-0246
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id7201832526
person.identifier.scopus-author-id7101806760
person.identifier.scopus-author-id56568523700
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationd354b937-b18c-4ca5-a843-04a04269d60f
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublication.latestForDiscoveryd354b937-b18c-4ca5-a843-04a04269d60f

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Parathyroid hormone-related protein regulates intestinal calcium transport in sea bream (Sparus auratus).pdf
Size:
328.43 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.61 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)