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FOXO family isoforms

2023-10Journal article Open access
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dc.contributor.authorSantos, Bruno F
dc.contributor.authorGrenho, Inês
dc.contributor.authorMartel, Paulo
dc.contributor.authorFerreira, Bibiana
dc.contributor.authorLink, Wolfgang
dc.date.accessioned2024-01-04T10:37:10Z
dc.date.available2024-01-04T10:37:10Z
dc.date.issued2023-10
dc.description.abstractFOXO family of proteins are transcription factors involved in many physiological and pathological processes including cellular homeostasis, stem cell maintenance, cancer, metabolic, and cardiovascular diseases. Genetic evidence has been accumulating to suggest a prominent role of FOXOs in lifespan regulation in animal systems from hydra, C elegans, Drosophila, and mice. Together with the observation that FOXO3 is the second most replicated gene associated with extreme human longevity suggests that pharmacological targeting of FOXO proteins can be a promising approach to treat cancer and other age-related diseases and extend life and health span. However, due to the broad range of cellular functions of the FOXO family members FOXO1, 3, 4, and 6, isoform-specific targeting of FOXOs might lead to greater benefits and cause fewer side effects. Therefore, a deeper understanding of the common and specific features of these proteins as well as their redundant and specific functions in our cells represents the basis of specific targeting strategies. In this review, we provide an overview of the evolution, structure, function, and disease-relevance of each of the FOXO family members.pt_PT
dc.description.sponsorshipAgencia Estatal de Investigation and the European Regional Development Fund (PID2022-136654OB-I00 financed by MCIN/AEI /10.13039/501100011033 / FEDER, UE).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1038/s41419-023-06177-1pt_PT
dc.identifier.issn2041-4889
dc.identifier.urihttp://hdl.handle.net/10400.1/20263
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringernaturept_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTranscripion factorspt_PT
dc.subjectForkhead Boxpt_PT
dc.subjectLife-spanpt_PT
dc.subjectGenept_PT
dc.subjectLongevitypt_PT
dc.subjectCancerpt_PT
dc.subjectDAF-16pt_PT
dc.subjectExpressionpt_PT
dc.subjectProteinspt_PT
dc.subjectGlucosept_PT
dc.titleFOXO family isoformspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMED-ONC%2F4167%2F2020/PT
oaire.citation.issue10pt_PT
oaire.citation.titleCell Death & Diseasept_PT
oaire.citation.volume14pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameSilva Santos
person.familyNameGrenho
person.familyNameMartel
person.familyNameferreira
person.familyNameLink
person.givenNameBruno Filipe
person.givenNameInês
person.givenNamePaulo
person.givenNameBibiana
person.givenNameWolfgang
person.identifier1955829
person.identifier803637
person.identifier.ciencia-id7012-6BCC-CC65
person.identifier.ciencia-idAD16-8C2A-26CE
person.identifier.ciencia-idA311-E925-09C5
person.identifier.ciencia-id6910-952E-242A
person.identifier.orcid0009-0006-4187-251X
person.identifier.orcid0000-0003-3777-9380
person.identifier.orcid0000-0001-8237-1267
person.identifier.orcid0000-0003-4772-9395
person.identifier.orcid0000-0002-3340-5165
person.identifier.ridK-4704-2013
person.identifier.scopus-author-id7101625192
person.identifier.scopus-author-id35368713800
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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