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β-Cyclodextrin and cucurbit[7]uril as protective encapsulation agents of the CO-releasing molecule [CpMo(CO)<sub>3</sub>Me]

2024Journal article Open access
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dc.contributor.authorMonteiro, Rodrigo P.
dc.contributor.authorCalhau, Isabel B.
dc.contributor.authorGomes, Ana C.
dc.contributor.authorD. Lopes, André
dc.contributor.authorDa Silva, José Paulo
dc.contributor.authorGonçalves, Isabel P.
dc.contributor.authorPillinger, Martyn
dc.date.accessioned2025-01-08T11:18:22Z
dc.date.available2025-01-08T11:18:22Z
dc.date.issued2024
dc.description.abstractThe CO releasing ability of the complex [CpMo(CO)3Me] (1) (Cp = eta 5-C5H5) has been assessed using a deoxymyoglobin-carbonmonoxymyoglobin assay. In the dark, CO release was shown to be promoted by the reducing agent sodium dithionite in a concentration-dependent manner. At lower dithionite concentrations, where dithionite-induced CO release was minimised, irradiation at 365 nm with a low-power UV lamp resulted in a strongly enhanced release of CO (half-life (t1/2) = 6.3 min), thus establishing complex 1 as a photochemically activated CO-releasing molecule. To modify the CO release behaviour of the tricarbonyl complex, the possibility of obtaining inclusion complexes between 1 and beta-cyclodextrin (beta CD) or cucurbit[7]uril (CB7) by liquid-liquid interfacial precipitation (1@beta CD(IP)), liquid antisolvent precipitation (1@CB7), and mechanochemical ball-milling (1@beta CD(BM)) was evaluated. All these methods led to the isolation of a true inclusion compound (albeit mixed with nonincluded 1 for 1@beta CD(BM)), as evidenced by powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA), FT-IR and FT-Raman spectroscopies, and 13C{1H} magic angle spinning (MAS) NMR. PXRD showed that 1@beta CD(IP) was microcrystalline with a channel-type crystal packing structure. High resolution mass spectrometry studies revealed the formation of aqueous phase 1 : 1 complexes between 1 and CB7. For 1@beta CD(IP) and 1@CB7, the protective effects of the hosts led to a decrease in the CO release rates with respect to nonincluded 1. beta CD had the strongest effect, with a ca. 10-fold increase in t1/4 for dithionite-induced CO release, and a ca. 2-fold increase in t1/2 for photoinduced CO release.eng
dc.description.sponsorshipEMBRC.PT ALG-01-0145-FEDER-022121, 022161, POCI-01-0145-FEDER-022161; CEECIND/02128/2017
dc.identifier.doi10.1039/d4dt01863j
dc.identifier.eissn1477-9234
dc.identifier.issn1477-9226
dc.identifier.urihttp://hdl.handle.net/10400.1/26590
dc.language.isoeng
dc.peerreviewedyes
dc.publisherRoyal Society of Chemistry
dc.relationCICECO-Aveiro Institute of Materials
dc.relationCICECO-Aveiro Institute of Materials
dc.relationCICECO – Aveiro Institute of Materials
dc.relationAlgarve Centre for Marine Sciences
dc.relationAlgarve Centre for Marine Sciences
dc.relationCentre for Marine and Environmental Research
dc.relationCEECIND/02128/2017
dc.relation.ispartofDalton Transactions
dc.rights.uriN/A
dc.subjectCarbon-monoxide
dc.subjectInclusion complexes
dc.subjectMetal-complexes
dc.subjectMolybdenum
dc.subjectToxicity
dc.subjectDelivery
dc.subjectMO
dc.subjectDerivatives
dc.subjectTitanocene
dc.subjectStability
dc.titleβ-Cyclodextrin and cucurbit[7]uril as protective encapsulation agents of the CO-releasing molecule [CpMo(CO)<sub>3</sub>Me]eng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCICECO-Aveiro Institute of Materials
oaire.awardTitleCICECO-Aveiro Institute of Materials
oaire.awardTitleCICECO – Aveiro Institute of Materials
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleAlgarve Centre for Marine Sciences
oaire.awardTitleCentre for Marine and Environmental Research
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50011%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0101%2F2020/PT
oaire.citation.endPage180
oaire.citation.issue54
oaire.citation.startPage166
oaire.citation.titleDalton Transactions
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameD. Lopes
person.familyNameDa Silva
person.givenNameAndré
person.givenNameJosé Paulo
person.identifier2824636
person.identifier.ciencia-id351E-856A-0300
person.identifier.ciencia-id3413-C4F4-73F7
person.identifier.orcid0000-0002-9702-1216
person.identifier.orcid0000-0002-6458-7328
person.identifier.ridE-2136-2012
person.identifier.ridA-4606-2008
person.identifier.scopus-author-id7201958625
person.identifier.scopus-author-id7201733236
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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