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Estrogen-responsive genes in macrophages of the bony fish gilthead seabream: a transcriptomic approach

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dc.contributor.authorLiarte, S.
dc.contributor.authorChaves-Pozo, E.
dc.contributor.authorAbellán, E.
dc.contributor.authorMeseguer, J.
dc.contributor.authorMulero, V.
dc.contributor.authorCanario, Adelino V. M.
dc.contributor.authorGarcía-Ayala, A.
dc.date.accessioned2014-05-09T14:45:36Z
dc.date.available2014-05-09T14:45:36Z
dc.date.issued2011
dc.date.updated2014-05-08T10:02:02Z
dc.description.abstractThe role of sex steroids in the modulation of fish immune responses has received little attention. Previous studies have demonstrated that 17 -estradiol (E2) is able to alter the response of gilthead seabream leukocytes to infectious agents. We have used suppression subtractive hybridization to identify genes upregulated by E2 (50 ng/ml) in macrophage cultures from gilthead seabream. We isolated 393 upregulated cDNA fragments that led to the identification of 162 candidate estrogen-responsive genes. Functional analyses revealed the presence of several enriched immune processes and molecular pathways. The E2 up-regulation of some immune-relevant genes was further confirmed by real time RT-PCR. Bioinformatics analysis revealed the ability of E2 to orchestrate profound alterations in the macrophage expression profile, especially immune-related processes and pathways. This is the first report on E2- dependent modifications of fish macrophage transcriptome and lends weight to a suggested role for estrogen in the immune system, the possible significance of which is discussed.por
dc.identifier.citationLiarte, S.; Chaves-Pozo, E.; Abellán, E.; Meseguer, J.; Mulero, V.; Canario, A.V.M.; García-Ayala, A. Estrogen-responsive genes in macrophages of the bony fish gilthead seabream: A transcriptomic approach, Developmental & Comparative Immunology, 35, 8, 840-849, 2011.por
dc.identifier.doihttp://dx.doi.org/10.1016/j.dci.2011.03.015
dc.identifier.issn0145-305X
dc.identifier.otherAUT: ACA00258;
dc.identifier.urihttp://hdl.handle.net/10400.1/3834
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectEstrogenspor
dc.subjectMacrophagespor
dc.subjectTranscriptomicpor
dc.subjectGilthead seabreampor
dc.titleEstrogen-responsive genes in macrophages of the bony fish gilthead seabream: a transcriptomic approachpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage849por
oaire.citation.issue8por
oaire.citation.startPage840por
oaire.citation.titleDevelopmental & Comparative Immunologypor
oaire.citation.volume35por
person.familyNameCanario
person.givenNameAdelino
person.identifier143624
person.identifier.ciencia-id1F1E-D3B3-F804
person.identifier.orcid0000-0002-6244-6468
person.identifier.ridC-7942-2009
person.identifier.scopus-author-id56568523700
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication5f6e51ee-9113-469e-8b9e-f30f2d452521
relation.isAuthorOfPublication.latestForDiscovery5f6e51ee-9113-469e-8b9e-f30f2d452521

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