Repository logo
 
Publication

Isolation and characterisation of the corticotropin releasing factor receptor 1 (CRFR1) gene in a teleost fish, Fugu rubripes

2003Journal article Restricted access
Simple item page
dc.contributor.authorCardoso, João CR
dc.contributor.authorPower, Deborah
dc.contributor.authorElgar, Greg
dc.contributor.authorClark, M. S.
dc.date.accessioned2014-10-24T10:56:29Z
dc.date.available2014-10-24T10:56:29Z
dc.date.issued2003
dc.description.abstractCorticotropin releasing factor receptor (CRF) is a member of the secretin family of the G-protein coupled receptor superfamily. These are characterised by the presence of seven transmembrane domains and six conserved cysteines that are important for receptor conformation and ligand binding. In vertebrates two CRF receptors (CRF1 and CRF2) have been isolated and characterised. In this study the complete structure of the CRF1 receptor was isolated and partially characterised for the first time in a vertebrate using the compact genome of the Japanese pufferfish, Fugu rubripes as a model. The Fugu CRF1 receptor gene is composed of 14 exons is approximately 27 kb in length. A tissue distribution of this receptor in Fugu reveals that it is expressed mainly in liver, gonads, heart and brain, however, expression in the kidney, gut and gills was also detected. In vertebrates this receptor appears to have a different tissue distribution and its presence in the gills may indicate a new role in osmoregulatory processes.por
dc.description.sponsorshipThis work was supported by an MRC grant to M.S.Clark and G.Elgar and a FCT plurianual grant to CCMAR, Portugal. D.M.Power was in receipt of a sabbatical grant (BLS58; FCT, Portugal). J.C.R.Cardoso was funded by FCT, Portugal (grant, BD/19925/99).por
dc.identifier.citationJoão C.R. Cardoso, Deborah Power, G. Elgar, Melody S. Clark, "Isolation and characterisation of the corticotropin releasing factor receptor 1 (CRFR1) gene in a teleost fish, Fugu rubripes." in DNA Sequence, June 2003 Vol. 14 (3), pp. 215–218.por
dc.identifier.doihttp://dx.doi.org/10.1080/1042517031000112624
dc.identifier.issn1042-5179
dc.identifier.otherAUT: DPO00386;
dc.identifier.urihttp://hdl.handle.net/10400.1/5472
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherTaylor&Francispor
dc.subjectCorticotropin releasing factor receptorpor
dc.subjectG-proteinpor
dc.subjectOsmoregulationpor
dc.subjectFugu rubripespor
dc.titleIsolation and characterisation of the corticotropin releasing factor receptor 1 (CRFR1) gene in a teleost fish, Fugu rubripespor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage218por
oaire.citation.issue3por
oaire.citation.startPage215por
oaire.citation.titleDNA Sequencepor
oaire.citation.volume14por
person.familyNameCardoso
person.familyNamePower
person.givenNameJoão
person.givenNameDeborah Mary
person.identifier14332
person.identifier.ciencia-id8B16-F203-2AFC
person.identifier.ciencia-id891A-8A44-3CAE
person.identifier.orcid0000-0001-7890-0170
person.identifier.orcid0000-0003-1366-0246
person.identifier.ridM-4151-2013
person.identifier.scopus-author-id7201822956
person.identifier.scopus-author-id7101806760
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication1b670c84-15e3-4776-8871-50f9eb0eed0d
relation.isAuthorOfPublicationc68f5ffb-63f6-4c70-8957-29e464fb59c0
relation.isAuthorOfPublication.latestForDiscoveryc68f5ffb-63f6-4c70-8957-29e464fb59c0

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Isolation and characterisation of the corticotropin releasing factor receptor 1 (CRFR1) gene in a teleost fish, Fugu rubripes..pdf
Size:
183.37 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
3.49 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CCM2-Artigos (em revistas ou actas indexadas)