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Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice

2025-02-27Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg10:Reduzir as Desigualdades
dc.contributor.authorFerreira-Marques, Marisa
dc.contributor.authorCarmo-Silva, Sara
dc.contributor.authorPereira, Joana
dc.contributor.authorBotelho, Mariana
dc.contributor.authorNóbrega, Clévio
dc.contributor.authorLópez‐Otín, Carlos
dc.contributor.authorAlmeida, Luís Pereira de
dc.contributor.authorAveleira, Célia A.
dc.contributor.authorCavadas, Cláudia
dc.date.accessioned2026-04-08T13:41:17Z
dc.date.available2026-04-08T13:41:17Z
dc.date.issued2025-02-27
dc.description.abstractThe hypothalamus has been recognized as a regulator of whole-body aging. Neuropeptide Y (NPY), highly abundant in the central nervous system and produced by the hypothalamus, enhances autophagy in this brain region and mediates autophagy triggered by caloric restriction, suggesting a potential role as a caloric restriction mimetic and an aging regulator. Considering that hypothalamic NPY levels decline during aging, we investigated if reestablishment of NPY levels mitigate aging phenotype, using a mouse model of premature aging – Zmpste24−/− mouse. The results show that reestablishing hypothalamic NPY levels delayed aging-associated features, including lipodystrophy, alopecia, and memory. Moreover, these results suggest that strategies that promote maintenance of hypothalamic NPY levels might be relevant to counteract aging progression and age-related deteriorations.eng
dc.description.sponsorshipPOCI-01–0145-FEDER-030167; COVID/BD/152130/2021; IF/00825/2015; LA/P/0058/2020
dc.identifier.doi10.1007/s11357-025-01574-0
dc.identifier.issn2509-2723
dc.identifier.urihttp://hdl.handle.net/10400.1/28620
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.relationCenter for Innovative Biomedicine and Biotechnology
dc.relationNeuropeptide Y NPY system as a new target to delay aging
dc.relation.ispartofGeroScience
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBiology of aging
dc.subjectBrain aging
dc.subjectHypothalamus
dc.subjectNeuropeptide Y
dc.titleRestoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in miceeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/04539/2020
oaire.awardNumberSFRH/BD/120023/2016
oaire.awardTitleCenter for Innovative Biomedicine and Biotechnology
oaire.awardTitleNeuropeptide Y NPY system as a new target to delay aging
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04539%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH%2FBD%2F120023%2F2016/PT
oaire.citation.endPage5801
oaire.citation.issue4
oaire.citation.startPage5785
oaire.citation.titleGeroScience
oaire.citation.volume47
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_CENTRO
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameNóbrega
person.givenNameClévio
person.identifier.ciencia-idC510-7F41-BAF8
person.identifier.orcid0000-0002-8312-5292
person.identifier.ridM-6047-2013
person.identifier.scopus-author-id24473454000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication725ea6f8-1363-4cee-9cf2-5ac7303b3ba9
relation.isAuthorOfPublication.latestForDiscovery725ea6f8-1363-4cee-9cf2-5ac7303b3ba9
relation.isProjectOfPublication428f397e-22dd-493a-b097-988a1717f76f
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relation.isProjectOfPublication.latestForDiscovery428f397e-22dd-493a-b097-988a1717f76f

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